Weeds have continually interrupted crop plants since their domestication, leading to a greater yield loss compared to diseases and pests that necessitated to practice weed control measures. The control of weeds is crucial to ensure the availability of sufficient food for rapidly increasing human population. Currently, the chemical (herbicides) weed control is the most effective, reliable, and widely used method of weed management programs. The application of herbicides for weed control practices called for the urgency to develop herbicide resistant (HR) crops. Recently, the genome editing tools, especially CRISPR-Cas9 has brought innovation in genome editing technology that opens up new possibilities to provide sustainable farming in modern agricultural industry. To date, several non-GM (genetically modified) HR crops have been developed through genome editing that can present a leading role to combat weed problem along with increased crop productivity to meet increasing food demand around the world. Here, we present various techniques of weed control, approaches for herbicide resistance development, and possible advantages and limitations of genome editing in herbicide resistance. We also discuss how genome editing would be effective in combating intensive weed problem and what would be the impact of genome-edited HR crops in agriculture.