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Comparing a Knowledge-based 3D Reconstruction Algorithm to TomTec 3D Echocardiogram Algorithm in Measuring Left Cardiac Chamber Volumes in the Pediatric population
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  • Attila Ahmad,
  • Sachie Shigemitsu,
  • Yozo Termachi,
  • Jonathan Windram,
  • Nee Scze Khoo,
  • Tim Colen,
  • Luke Eckersley
Attila Ahmad
University of Alberta

Corresponding Author:[email protected]

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Sachie Shigemitsu
University of Alberta
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Yozo Termachi
University of Alberta
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Jonathan Windram
University of Alberta
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Nee Scze Khoo
University of Alberta
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Tim Colen
University of Alberta
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Luke Eckersley
University of Alberta
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Background: Three-dimensional echocardiography (3DE) is an emerging method for volumetric cardiac measurements; however, few vendor-neutral analysis packages exist. Ventripoint Medical System Plus (VMS3.0+) proprietary software utilizes a validated MRI database of normal ventricular and atrial morphologies to calculate chamber volumes. This study aimed to compare left ventricular (LV) and atrial (LA) volumes obtained using VMS3.0+ to Tomtec echocardiography analysis software. Methods: Healthy controls (n=98) aged 0 to 18 years were prospectively recruited and 3D DICOM datasets focused on the LV and LA acquired. LV and LA volumes and ejection fractions were measured using TomTec Image Arena 3D LV analysis package and using VMS3.0+. Pearson correlation coefficients, Bland-Altman’s plots and intraclass coefficients (ICC) were calculated, along with analysis time. Results: There was a very good correlation between VMS and Tomtec LV systolic (r 2 = 0.88, ICC 0.89 [95% CI 0.81,0.94]), and diastolic (r 2 = 0.88, ICC 0.90 [95% CI 0.77,0.95]) volumes, and between VMS and Tomtec LA diastolic (r 2 =0.75, ICC 0.89 [95% CI 0.81,0.93]) and systolic (r 2 =0.88, ICC 0.91 [95% CI 0.78,0.96]) volumes on linear regression models. Natural log transformations eliminated heteroscedasticity, and power transformations provided best fit. The time (mins) to analyze volumes using VMS were less than using Tomtec (LV VMS 2.3±0.5, Tomtec 3.3±0.8, p<0.001; LA: VMS 1.9±0.4, Tomtec 3.4±1.0, p<0.001). Conclusions: There was very good correlation between knowledge-based (VMS3.0+) and 3D (Tomtec) algorithms when measuring 3D echocardiography derived LA and LV volumes in pediatric patients. VMS was slightly faster than Tomtec in analyzing volumetric measurements.
11 Feb 2022Submitted to Echocardiography
11 Feb 2022Submission Checks Completed
11 Feb 2022Assigned to Editor
28 Mar 2022Reviewer(s) Assigned
13 Apr 2022Review(s) Completed, Editorial Evaluation Pending
10 May 2022Editorial Decision: Revise Minor
13 May 20221st Revision Received
17 May 2022Submission Checks Completed
17 May 2022Assigned to Editor
17 May 2022Reviewer(s) Assigned
04 Jun 2022Review(s) Completed, Editorial Evaluation Pending
01 Jul 2022Editorial Decision: Accept
Sep 2022Published in Echocardiography volume 39 issue 9 on pages 1180-1189. 10.1111/echo.15427