Emergence of a novel recombinant porcine circovirus type 2b (PCV2b) and
PCV2d in Thailand
Abstract
Porcine circovirus type 2 (PCV2) has been recognized as a causative
agent of porcine circovirus-associated diseases (PCVAD) affecting the
global swine industry for more than three decades. The high mutation
rate of PCV2 can lead to rapid evolution and emergence of novel PCV2
strains. In this study, we investigated the genetic diversity of PCV2
strains circulating in Thailand between 2019-2020. From 734 samples (145
farms), 396 (54.0%) samples obtained from 118 farms were positive for
PCV2. Of these, whole-genome sequences of 51 Thai PCV2 strains were
analyzed and assigned to PCV2d (86.3%) and PCV2b (13.7%). The complete
genomic analysis also revealed an intergenotypic recombinant virus
between PCV2b and PCV2d. Our findings and viral sequence dataset provide
essential information on the genetic diversity of PCV2, including the
evidence of novel intergenotypic recombination of PCV2 in Thailand.