Lynch syndrome (LS) is the most common hereditary colon cancer syndrome
caused by germline mutations in mismatch repair (MMR) genes. In this
series, we outline 3 pediatric patients who presented with vague
symptoms due to colorectal cancer who were eventually diagnosed with
Lynch syndrome with multiple gene mutations. The diagnosis of colorectal
cancer in pediatrics warrants timely recognition, inclusion of Lynch
syndrome in the differential diagnosis, multi-gene testing, and genetic
counseling for the patient and family.