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The role of shared risk factors for COVID-19 and preeclampsia: An observational study
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  • Berta Serrano,
  • Manel Mendoza,
  • Paula Garcia-Aguilar,
  • Erika Bonacina,
  • Itziar Garcia-Ruiz,
  • Pablo Garcia-Manau,
  • Judit Gil,
  • Mireia Armengol,
  • Nuria Fernández-Hidalgo,
  • Elena Sulleiro,
  • Rosa Maria Lopez-Martinez,
  • Marta Ricart,
  • Lourdes Martin,
  • Eva Lopez-Quesada,
  • Angels Vives,
  • Anna Maroto,
  • Nerea Maiz,
  • Anna Suy,
  • Elena Carreras
Berta Serrano
Vall d'Hebron Hospital
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Manel Mendoza
Vall d'Hebron Hospital
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Paula Garcia-Aguilar
Vall d'Hebron Hospital
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Erika Bonacina
Vall d'Hebron Hospital
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Itziar Garcia-Ruiz
Vall d'Hebron University Hospital
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Pablo Garcia-Manau
Vall d'Hebron Hospital
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Judit Gil
Hospital Universitari Vall d'Hebron
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Mireia Armengol
Vall d'Hebron Hospital
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Nuria Fernández-Hidalgo
Vall d'Hebron University Hospital
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Elena Sulleiro
Vall d'Hebron Hospital Universitari
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Rosa Maria Lopez-Martinez
Vall d'Hebron Hospital
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Marta Ricart
University Hospital Germans Trias i Pujol
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Lourdes Martin
Joan XXIII University Hospital in Tarragona
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Eva Lopez-Quesada
Grup Mutua Terrassa
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Angels Vives
Consorci Sanitari de Terrassa
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Anna Maroto
Doctor Josep Trueta University Hospital of Girona
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Nerea Maiz
Hospital Universitari Vall d'Hebron
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Anna Suy
Vall d'Hebron University Hospital
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Elena Carreras
Vall d'Hebron University Hospital
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Abstract

Objective: To examine baseline risk factors measured in the first-trimester screening for preeclampsia (PE) in pregnant women with COVID-19 versus the general population. To compare risk factors among patients with mild and severe COVID-19. Design: Observational retrospective study. Setting: Six maternities in Catalonia. Population: Study patients were 231 pregnant women undergoing first-trimester screening for PE and positive for SARS-CoV-2. Reference cohort were 13,033 pregnant women with first-trimester screening for PE from 6 maternities. Methods: Recording of maternal history, mean arterial blood pressure (MAP), mean uterine artery pulsatility index (UtAPI), placental growth factor (PlGF) and pregnancy-associated plasma protein-A at first trimester. Confirmation of SARS-CoV-2 infection. Based on the need for hospitalization, patients were classified into mild and severe COVID-19. Main outcome measures: Comparison of proportion of cases at a high risk for PE and of risk factors for PE among groups. Results: High risk for PE was significantly higher amongst COVID-19 patients compared to the general population, showing higher rates of obesity, chronic hypertension, higher UtAPI, and lower rates of smokers. PlGF did not differ significantly. In women with severe COVID-19, compared with mild COVID-19, BMI and MAP were significantly higher, whereas PlGF and UtAPI did not differ significantly. Conclusions: In patients with COVID-19 there was a higher proportion of women at a high risk for PE than in the general population, mainly due to maternal risk factors, rather than placental signs of a deficient trophoblastic invasion. Likewise, according to COVID-19 severity, differences were due to maternal risk factors only.