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Dynamics and optimal control of a spatial diffusion HIV/AIDS model with ART and PrEP treatments
  • Liping Wang,
  • Anwarud Din,
  • Peng Wu
Liping Wang
Anhui Polytechnic University

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Anwarud Din
Sun Yat-Sen University
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Peng Wu
Zhejiang University of Finance and Economics
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In this paper, to investigate the synthetic effect of PrEP (pre-exposure prophylaxis) and ART (antiretrovial therapy) on HIV transmission among MSM (men who have sex with men) in heterogenous environment, an realistic HIV epidemic model with spatial diffusion is established. Here, HIV infectious people are divided into three immunity based compartments, i.e., CD4+ T cell count less than 350, between 350 and 500, and more than 500, respectively. The basic reproduction number $R_0$ is established and proved as a threshold parameter: The global asymptotic stability of the disease-free steady state holds for $R_0<1$, and the disease will be present if $R_0>1$. Considering the substantial advantages of PrEP and ART in controlling HIV transmissions among MSM, the optimal control problem is presented for the case of positive constant diffusion coefficients, which minimize the total population of susceptible individual and HIV infected individual, the cost of PrEP and ART thearpy. As an illustration of our theoretical results, we conduct numerical simulations. We also conduct an optimal control case study where model parameters are estimated from the demographic and epidemiological data from China. This work suggests: (1) Spatial factors cannot be ignored during the HIV intervention; (2)Taking the PrEP intervention measure for HIV transmissions among MSM as early as possible will help to improve the control efficiency and reduces its cost; (3) Reducing the PrEP drug costs will promote the efficiency of PrEP treatment in preventing the spread of HIV among MSM.
01 Jan 2022Submitted to Mathematical Methods in the Applied Sciences
03 Jan 2022Submission Checks Completed
03 Jan 2022Assigned to Editor
12 Jan 2022Reviewer(s) Assigned
10 Apr 2022Review(s) Completed, Editorial Evaluation Pending
10 Apr 2022Editorial Decision: Revise Minor
14 Apr 20221st Revision Received
15 Apr 2022Submission Checks Completed
15 Apr 2022Assigned to Editor
15 Apr 2022Reviewer(s) Assigned
16 Apr 2022Review(s) Completed, Editorial Evaluation Pending
18 Apr 2022Editorial Decision: Accept
Published in SSRN Electronic Journal. 10.2139/ssrn.4011815