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Food allergy in early childhood increases the risk of pollen-food allergy syndrome
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  • Kun Baek Song,
  • Min Jee Park,
  • Eom Ji Choi,
  • Sungsu Jung,
  • Ji-Sun Yoon,
  • Hyun-Ju Cho,
  • Bong-Seong Kim,
  • Kangmo Ahn,
  • Kyung Won Kim,
  • Youn Ho Shin,
  • Dong In Suh,
  • Soo-Jong Hong,
  • So-Yeon Lee
Kun Baek Song
Asan Medical Center

Corresponding Author:[email protected]

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Min Jee Park
Uijeongbu Eulji University Hospital
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Eom Ji Choi
Asan Medical Center
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Sungsu Jung
Pusan National University Yangsan Hospital
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Ji-Sun Yoon
Chung Ang University Hospital
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Hyun-Ju Cho
Catholic Kwandong University International Saint Mary's Hospital
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Bong-Seong Kim
Gangneung Asan Hospital
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Kangmo Ahn
Samsung Medical Center
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Kyung Won Kim
Severance Hospital
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Youn Ho Shin
CHA Gangnam Medical Center, CHA University School of Medicine
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Dong In Suh
Seoul National University Children's Hospital
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Soo-Jong Hong
Asan Medical Center
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So-Yeon Lee
Asan Medical Center
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Abstract Background: The level of pollen in Korea has increased over recent decades. Research suggests that pollen-food allergy syndrome (PFAS) may be more frequent in childhood than previously recognized. We aimed to investigate the prevalence and characteristics of PFAS in children aged 6–10 years from a general population-based birth cohort. Methods: We analyzed 930 children from the COhort for Childhood Origin of Asthma and allergic diseases (COCOA) birth cohort. Allergic diseases were diagnosed annually by pediatric allergists. The skin prick tests were performed with 14 common inhalant allergens and four food allergens for children aged 3 and 7 years. Results: Of the 930 eligible children, 44 (4.7%) aged 6–10 years were diagnosed with. The mean age at onset was 6.74 years. PFAS prevalence was 7.2% among children with allergic rhinitis (AR) and 19.1% among those with pollinosis, depending on comorbidity. PFAS was more prevalent in schoolchildren with atopic dermatitis, food allergy, and sensitization to food allergens and grass pollen in early childhood. In schoolchildren with AR, only a history of food allergy before 3 years increased the risk of PFAS (aOR 2.971, 95% CI: 1.159–7.615). Conclusion: Food allergy and food sensitization in early childhood was associated with PFAS in schoolchildren with AR. Further study is required to elucidate the mechanism by which food allergy in early childhood affects the development of PFAS.
18 Dec 2021Submitted to Pediatric Allergy and Immunology
06 Jan 2022Reviewer(s) Assigned
22 Jan 2022Review(s) Completed, Editorial Evaluation Pending
24 Jan 2022Editorial Decision: Revise Major
01 Apr 20221st Revision Received
01 Apr 2022Review(s) Completed, Editorial Evaluation Pending
02 Apr 2022Reviewer(s) Assigned
25 Apr 2022Editorial Decision: Accept