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Do clinimetric properties of LCI change after correction of signal processing?
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  • Bettina Frauchiger,
  • Marc-Alexander Oestreich,
  • Florian Wyler,
  • Nathalie Monney,
  • Corin Willers,
  • Sophie Yammine,
  • Philipp Latzin
Bettina Frauchiger
Inselspital University Hospital Bern

Corresponding Author:bettina.frauchiger@insel.ch

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Marc-Alexander Oestreich
Inselspital Bern Universitatsklinik fur Kinderheilkunde
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Florian Wyler
Inselspital Bern Universitätsklinik für Kinderheilkunde
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Nathalie Monney
Inselspital Universitatsspital Bern
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Corin Willers
Inselspital Universitatsspital Bern
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Sophie Yammine
Inselspital University Hospital Bern
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Philipp Latzin
Inselspital University Hospital Bern
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Background: The recently described sensor-crosstalk error in the multiple-breath washout (MBW) device (Exhalyzer D, Eco Medics AG, Duernten, Switzerland) could highly influence clinimetric properties and the current interpretation of MBW results. This study reanalyzes MBW data from clinical routine in the corrected software version Spiroware® 3.3.1 and evaluates the effect on outcomes. Methods: We included nitrogen-MBW data from healthy children and children with CF from previously published trials and ongoing cohort studies. We specifically compared LCI analyzed in Spiroware 3.2.1 and 3.3.1 with regards to i) feasibility, ii) repeatability and iii) validity as outcome parameters in children with CF. Results: (i) All previously collected measurements could be reanalyzed and resulted in unchanged feasibility in Spiroware 3.3.1. (ii) Short- and midterm repeatability of LCI was similar in both software versions. (iii) Clinical validity of LCI remained similar in Spiroware 3.3.1, however, resulted in lower values. Discrimination between health and disease was comparable between both software versions. The increase in LCI over time was less pronounced with 0.16 LCI units/year (95% CI 0.08; 0.24) vs. 0.30 LCI units/year (95% CI 0.21; 0.38) in 3.2.1. Response to intervention in children receiving CFTR-modulator therapy resulted in a comparable improvement in LCI in both Spiroware versions. Conclusion: Our study confirms that clinimetric properties of LCI remain unaffected after correction for the cross-sensitivity error in Spiroware software.
21 Dec 2021Submitted to Pediatric Pulmonology
22 Dec 2021Submission Checks Completed
22 Dec 2021Assigned to Editor
24 Dec 2021Reviewer(s) Assigned
30 Jan 2022Review(s) Completed, Editorial Evaluation Pending
30 Jan 2022Editorial Decision: Revise Minor
31 Jan 20221st Revision Received
01 Feb 2022Submission Checks Completed
01 Feb 2022Assigned to Editor
01 Feb 2022Reviewer(s) Assigned
07 Feb 2022Review(s) Completed, Editorial Evaluation Pending
12 Feb 2022Editorial Decision: Accept
May 2022Published in Pediatric Pulmonology volume 57 issue 5 on pages 1180-1187. 10.1002/ppul.25865