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Burden of severe illness associated with laboratory confirmed influenza in adults aged 50-64 years: a rapid review
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  • Dong Kim,
  • Allison McGeer,
  • Elizabeth Uleryk,
  • Brenda Coleman
Dong Kim
Sinai Health System

Corresponding Author:[email protected]

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Allison McGeer
Sinai Health System
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Elizabeth Uleryk
Elizabeth M Uleryk Consultng
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Brenda Coleman
Sinai Health System
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Background: While the high burden of illness caused by seasonal influenza in children and the elderly is well-recognized, less is known about the burden in adults 50-64 years of age. The lack of data for this age group is a key challenge in evaluating the cost-effectiveness of vaccination programs. We aimed to assess influenza-associated hospitalization and mortality rates, and case fatality rates for hospitalized cases among adults aged 50-64 years. Methods: This review was conducted according to the PRISMA: we searched MEDLINE, EMBASE, Cochrane, Web of Science, and grey literature for articles and reports published since 2010. Studies reporting rates of hospitalization and/or mortality associated with laboratory-confirmed influenza among adults 50-64 or 45-64 years of age for the 2010-11 through 2019-20 seasons were included. Results: Twenty studies from 13 countries were included. Reported hospitalization rates associated with laboratory-confirmed influenza 5.7 to 112.8 per 100,000. Rates tended to be higher in 2015-2019 compared to 2010-2014, and were higher in studies reporting data from high income versus low and middle-income countries. Mortality rates were reported in only one study, with rates ranging from 0.8-3.5 per 100,000 in four different seasons. The case fatality rate among those hospitalized with influenza, as reported by population-based studies, ranged from 1.3% to 5.6%. Conclusions: Seasonal influenza imposes a significant burden of morbidity in adults 50-64 years of age, but with high heterogeneity across seasons and geographic regions. Ongoing surveillance is required to improve estimates of burden to better inform influenza vaccination and other public health policy.
17 Nov 2021Submitted to Influenza and other respiratory viruses
17 Nov 2021Assigned to Editor
17 Nov 2021Submission Checks Completed
05 Dec 2021Editorial Decision: Accept
19 Jan 2022Published in Influenza and Other Respiratory Viruses. 10.1111/irv.12955