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Genetic redundancy resolves invasion paradox in Colorado potato beetle
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  • Fangyuan Yang,
  • Michael Crossley,
  • Lukas Schrader,
  • Ivan Dubovskiy,
  • Runzhi Zhang
Fangyuan Yang

Corresponding Author:[email protected]

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Michael Crossley
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Lukas Schrader
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Ivan Dubovskiy
Institute of Systematics and Ecology of Animals Siberian Branch, Russian Academy of Sciences
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Runzhi Zhang
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The paradox of how invasive species cope with novel selective pressures with limited genetic variation is a fundamental question in molecular ecology. Several mechanisms have been proposed, but they can lack generality and predictive power. Here, we introduce an alternative mechanism, genetic redundancy, wherein changes in multiple combinations of loci can achieve a fitness optimum for polygenic traits, and thus the variations left after the founder effect may be sufficient for adaptation. We tested the potential importance of genetic redundancy in environmental adaptation of Colorado potato beetle (CPB) in introduced Eurasia. Population genomic analyses showed substantial genetic depletion following a single introduction event, which supports invasive CPB as a classic system for the paradox study. Genome-environment association analyses revealed a suite of loci and gene functions plausibly related to cold stress. Notably, a substantial portion of loci showed different contributions to similar or identical environments. Such non-parallel evolution indicates their potential redundancy to overall fitness. Furthermore, one important adaptive gene function, “phospholipid production”, was represented by more than one independent linkage cluster, suggesting some gene functional redundancy in cold resistance. Taken together, these results support the hypothesis that genetic redundancy can promote the adaptability of polygenic traits despite strong genetic depletion, thus providing a general mechanism for resolving the genetic paradox of invasion. More broadly, genetic redundancy, as an inherent feature of the genome, may have contributed to the evolutionary success of invasive species in many aspects.
01 Oct 2021Submitted to Molecular Ecology
04 Oct 2021Submission Checks Completed
04 Oct 2021Assigned to Editor
31 Oct 2021Reviewer(s) Assigned
07 Jan 2022Review(s) Completed, Editorial Evaluation Pending
07 Jan 2022Editorial Decision: Revise Minor
19 Jan 2022Review(s) Completed, Editorial Evaluation Pending
19 Jan 20221st Revision Received
01 Feb 2022Reviewer(s) Assigned
04 Apr 2022Editorial Decision: Revise Minor
15 Apr 2022Review(s) Completed, Editorial Evaluation Pending
15 Apr 20222nd Revision Received
02 Jun 2022Reviewer(s) Assigned
07 Jun 2022Editorial Decision: Revise Minor
04 Jul 2022Review(s) Completed, Editorial Evaluation Pending
04 Jul 20223rd Revision Received
15 Aug 2022Editorial Decision: Accept