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The form of PEG matters: PEG conjugated with lipids and not PEG alone could be the specific form involved in allergic reactions to COVID-19 vaccines
  • Natalija Novak2, Cezmi A. Akdis3,4 Beatriz Cabanillas1*,
  • Natalija Novak,
  • Cezmi Akdis A
Natalija Novak2, Cezmi A. Akdis3,4 Beatriz Cabanillas1*
Instituto de Investigacion Hospital 12 de Octubre

Corresponding Author:[email protected]

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Natalija Novak
Universitatsklinikum Bonn
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Cezmi Akdis A
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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Initial guidelines advised that sensitization to PEG should be taken into consideration in suspected subjects before a recommendation on the administration of vaccines for COVID-19 containing PEG or its cross-reactive analogues. 3 However, PEG shows an important variability in terms of molecular weights and conjugation forms. In that sense, although it is known that PEG-2000 (MW: 2000g/mol) conjugated with lipids is the form contained in the vaccines for COVID-19, there has been great variability in the PEG molecules used in allergy tests to evaluate sensitization of suspected subjects in the context of the current COVID-19 vaccination campaigns. 4 In this context, recent findings have shed light on the specific form of PEG that could be responsible of the hypersensitivity reactions to the mRNA vaccines for COVID-19.
29 Sep 2021Submitted to Allergy
01 Oct 2021Submission Checks Completed
01 Oct 2021Assigned to Editor
04 Oct 2021Reviewer(s) Assigned
18 Oct 2021Review(s) Completed, Editorial Evaluation Pending
19 Oct 2021Editorial Decision: Revise Minor
05 Nov 20211st Revision Received
05 Nov 2021Submission Checks Completed
05 Nov 2021Assigned to Editor
06 Nov 2021Reviewer(s) Assigned
09 Nov 2021Review(s) Completed, Editorial Evaluation Pending
21 Nov 2021Editorial Decision: Accept