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Low Neonatal Circumcision Bleeding Rate in Patients Diagnosed with Delta-Storage Pool Deficiency Later in Life
  • Hebah Al Absi,
  • Stein Dagmar
Hebah Al Absi
University of Toledo

Corresponding Author:[email protected]

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Stein Dagmar
ProMedica Toledo Children's Hospital
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Introduction male circumcision is a common procedure, generally performed during the newborn period. Few reports have described circumcision in patients with bleeding disorders. Aim to determine bleeding rate after circumcision in neonatal male subjects who were diagnosed later in life with delta-storage pool disease (SPD). Methods we retrospectively reviewed the medical records of male subjects (<18 years of age) who were diagnosed with SPD later in life and were circumcised at birth without hemostatic prophylaxis due to lack of family history at that time from 2000-2020. Intraoperative/postoperative bleeding and bleeding severity were the main outcomes evaluated. Results 153 male subjects were included. Circumcision was performed at a median age of 2 days (range, 1 day-4 months). The main indication for circumcision was parental request. Median severity of granule deficiency was 2.76 dense granules/platelet (range, 1.12-3.82 DG/Plt). None of the subjects had intraoperative bleeding. Three subjects (2%) had postoperative bleeding and only one (0.65%) required ER intervention to stop bleeding. Conclusion the overall incidence of bleeding in our subjects with SPD who were undiagnosed and untreated at circumcision, is comparable to that reported for patients without a bleeding disorder.
18 Sep 2021Submission Checks Completed
18 Sep 2021Assigned to Editor
18 Sep 2021Submitted to Pediatric Blood & Cancer
26 Sep 2021Review(s) Completed, Editorial Evaluation Pending
27 Sep 2021Reviewer(s) Assigned
20 Oct 2021Editorial Decision: Revise Major
13 Dec 20211st Revision Received
13 Dec 2021Assigned to Editor
13 Dec 2021Submission Checks Completed
24 Dec 2021Reviewer(s) Assigned
06 Jan 2022Review(s) Completed, Editorial Evaluation Pending
12 Jan 2022Editorial Decision: Revise Minor
22 Jan 2022Submission Checks Completed
22 Jan 2022Assigned to Editor
22 Jan 20222nd Revision Received
24 Jan 2022Reviewer(s) Assigned
28 Jan 2022Review(s) Completed, Editorial Evaluation Pending
01 Feb 2022Editorial Decision: Accept