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Young Cystic Fibrosis Lung Transplant Recipients: Predisposing Factors for End-stage Disease
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  • George Mallory,
  • Ernestina Melicoff,
  • Fadel Ruiz,
  • Kathleen Hosek
George Mallory
Texas Children's Hospital

Corresponding Author:[email protected]

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Ernestina Melicoff
Baylor College of Medicine
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Fadel Ruiz
Baylor College of Medicine
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Kathleen Hosek
Texas Children's Hospital
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Background: The largest age group among children and adolescents referred for lung transplantation for cystic fibrosis (CF) have been those who in the pubertal or post pubertal age range. However, over 100 younger patients with CF have undergone lung transplantation over the last three decades in the USA. Methods: We performed a retrospective review of our experience with 18 children with CF who underwent lung transplantation in our center before the age of 11 years. Results: Notable findings were a high prevalence of methicillin-resistant Staphylococcus aureus, a high prevalence of diabetes mellitus and an impressive prevalence of consolidated lobar or whole lung disease. Post-transplant outcomes, however, were comparable to those older than 10 years of age in our center. Conclusions: In an era of increasingly effective medications modifying the natural history of CF, identification of risk factors for early severe lung disease in CF remains relevant and potentially more important for effective intervention in order to extend life.
22 Sep 2021Submitted to Pediatric Pulmonology
23 Sep 2021Submission Checks Completed
23 Sep 2021Assigned to Editor
24 Sep 2021Reviewer(s) Assigned
04 Nov 2021Review(s) Completed, Editorial Evaluation Pending
05 Nov 2021Editorial Decision: Revise Major
15 Nov 20211st Revision Received
16 Nov 2021Assigned to Editor
16 Nov 2021Submission Checks Completed
16 Nov 2021Reviewer(s) Assigned
09 Dec 2021Review(s) Completed, Editorial Evaluation Pending
12 Dec 2021Editorial Decision: Revise Minor
29 Dec 20212nd Revision Received
30 Dec 2021Submission Checks Completed
30 Dec 2021Assigned to Editor
30 Dec 2021Reviewer(s) Assigned
19 Jan 2022Review(s) Completed, Editorial Evaluation Pending
20 Jan 2022Editorial Decision: Revise Minor
02 Feb 20223rd Revision Received
03 Feb 2022Assigned to Editor
03 Feb 2022Submission Checks Completed
03 Feb 2022Reviewer(s) Assigned
07 Feb 2022Review(s) Completed, Editorial Evaluation Pending
12 Feb 2022Editorial Decision: Accept