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Diagnosis and management of neutropenia in children: consensus audit of the “Associazione Italiana Ematologia Oncologia Pediatrica” (AIEOP) experts
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  • Francesca Fioredda,
  • Daniela Onofrillo,
  • Piero Farruggia,
  • Angelica Barone,
  • Marinella Veltroni ,
  • Lucia Notarangelo,
  • Giuseppe Menna,
  • Giovanna Russo,
  • Baldo Martire ,
  • Andrea Finocchi,
  • Federico Verzegnassi ,
  • Sonia Bonanomi,
  • Ugo Ramenghi,
  • Marta Pillon,
  • Carlo Dufour
Francesca Fioredda
IRCCS–Istituto Giannina Gaslini

Corresponding Author:[email protected]

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Daniela Onofrillo
Spirito Santo Hospital
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Piero Farruggia
A.R.N.A.S. Ospedale Civico Di Cristina e Benfratelli
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Angelica Barone
University of Parma
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Marinella Veltroni
Azienda Ospedaliero Universitaria Meyer
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Lucia Notarangelo
Children's Hospital, Spedali Civili
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Giuseppe Menna
AORN (Azienda Ospedaliera Rilievo Nazionale), Santobono Pausillipon
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Giovanna Russo
Azienda Policlinico-Vittorio Emanuele, University of Catania
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Baldo Martire
"Monsignor Dimiccoli" Hospital
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Andrea Finocchi
University Department of Pediatrics DPUO, Children's Hospital Bambino Gesù, IRCCS
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Federico Verzegnassi
IRCCS Materno Infantile Burlo Garofolo
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Sonia Bonanomi
MBBM Foundation, University of Milano-Bicocca, Monza, Italy
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Ugo Ramenghi
University of Torino
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Marta Pillon
University Hospital of Padua
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Carlo Dufour
Istituto Giannina Gaslini
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Abstract

SUMMARY Neutropenia is a generic term that indicates a reduction of neutrophils below the threshold for age and race. This condition encompasses a number of diseases with a wide range of duration and severity. In the present paper, the approach to diagnosis and treatment of neutropenia has been reviewed and implemented with the knowledge acquired during the last decade, by a group of experts, 10 years after the first publication. The diagnostic itinerary highlights the most important tools available to define the type of neutropenia and updates the list of genes causative of the disease. In addition, the present paper underlines the progresses towards a better definition of “primary autoimmune neutropenia” without remission which often hides different diseases. Moreover, indications on how to speed up neutropenia diagnosis and the indications to perform the bone marrow examination in the genetic forms, are given. The management and treatment of the “well-known” diseases and “special situations” are also reviewed giving literature derived and expert opinion-based suggestions tailored on the single patient/diagnosis.