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Metabolic Reprogramming and Intervention During T Cell Exhaustion
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  • Fei Li,
  • Huiling Liu,
  • Dan Zhang,
  • Bingdong Zhu
Fei Li
Lanzhou University

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Huiling Liu
Gansu Provincial Hospital
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Dan Zhang
Lanzhou University
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Bingdong Zhu
Lanzhou University
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Recent studies have shown that T cell metabolism has become a key regulator of T cell function and even can determine T cell function at last. Naïve T cells use fatty acid oxidation (FAO) to meet their energetic demands. Effector T cells mainly rely on aerobic glycolysis to supply energy and synthesize intermediate products. Similar to naïve T cells, memory T cells primarily utilize FAO for energy. Exhausted T cells, which can be induced by continuous activation of T cells upon persistently chronic infections such as tuberculosis, mainly rely on glycolysis for energy. The prevention and treatment of T cell exhaustion is facing great challenges. Interfering T cell metabolism may achieve the goal of prevention and treatment of T cell exhaustion. In this review, we compiled the researches related to exhausted T cell metabolism and put forward the metabolic intervention strategies to reverse T cell exhaustion at different stages to achieve the purpose of preventing and treating T cell exhaustion.
12 Aug 2021Submitted to Clinical & Experimental Immunology
16 Aug 2021Assigned to Editor
16 Aug 2021Submission Checks Completed
16 Aug 2021Reviewer(s) Assigned