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Letter to editor: Evaluation of the relationship between TREM- 1/TREM- 2 ratio and clinical course in COVID- 19 pneumonia
  • zhihong wang
zhihong wang
Huzhou Central Hospital

Corresponding Author:[email protected]

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Dear editor, we read with great interest the well written article by Dr Kerget et al with the main objective of investigating the role of TREM-1/TREM-2 ratio on patients with COVID-19 pneumonia. The article pointed that TREM-1 and TREM-2 have important role in inflammation and TREM-1/TREM-2 ratio was higher in severe COVID-19 patients compared with moderate COVID-19 patients. We have certain comments to understand the conclusions of this article. Firstly, triggering receptor expressed on myeloid cells-1 (TREM-1) is mainly express on neutrophils and monocytes in a cell membrane-bound form. A soluble form of TREM-1(sTREM-1), which lacks the cytoplasmic tail and transmembrane part, were detected in the blood in recent studies. Since you have mentioned “serum TREM-1”, we were confused whether you detected TREM-1 or sTREM-1. Secondly, we wanted to know more about the treatment and the kidney functions of the patients. Thirdly, We are curious to see if high TREM-1/TREM-2 ratio could predict the distribution of ILD. We would be glad to hear the opinion of the author on the points, to get a more convincing conclusion.
14 Aug 2021Submitted to International Journal of Clinical Practice
14 Aug 2021Assigned to Editor
14 Aug 2021Submission Checks Completed
14 Aug 2021Review(s) Completed, Editorial Evaluation Pending
26 Aug 2021Reviewer(s) Assigned
10 Sep 2021Editorial Decision: Accept
Dec 2021Published in International Journal of Clinical Practice volume 75 issue 12. 10.1111/ijcp.14929