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ultrastrutal investigation on Pseudo Chediak–Higashi abnormality in acute lymphoblastic leukemia: A case report
  • +2
  • Jing Liu,
  • Shu-xu Dong,
  • Ying Li,
  • Yi-dan Xu,
  • Yong-xin Ru
Jing Liu
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

Corresponding Author:[email protected]

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Shu-xu Dong
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
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Ying Li
Tianjin Neurological Institute, Tianjin Medical University General Hospital
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Yi-dan Xu
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
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Yong-xin Ru
Chinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Experimental Hematology
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Abstract

Pseudo Chediak-Higashi (PCH) granules are mainly common in acute myeloid leukemia. Here we found a patient diagnosed with common-B acute lymphoblastic leukemia(ALL) with PCH cytoplasmic granules, which was rarely seen in daily diagnosis. The morphology of the granules is different in transmission electron microscope (TEM) from cases reported before. There is a vesicle with various-sized particles surrounding the nucleus, in addition to the particles, a multiple-layer membrane structure was also detected in the vesicle.