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Viral Filtration: A Review of Current and Future Practices in Bioprocessing
  • +4
  • Sarah Johnson,
  • Shuang Chen,
  • Glen Bolton,
  • Qi Chen,
  • Scott Lute,
  • John Fisher,
  • Kurt Brorson
Sarah Johnson
FDA
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Shuang Chen
NGM Biopharmaceuticals Inc
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Glen Bolton
Amgen Inc
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Qi Chen
Genentech Inc
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Scott Lute
FDA, CDER/OPS/OBP
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John Fisher
Genentech Inc
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Kurt Brorson
PAREXEL International
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Abstract

For drug products manufactured in mammalian cells, safety assurance practices are needed during production to assure that the final medicinal product is safe from the potential risk of viral contamination. Virus filters provide viral retention for a range of viruses through robust, size-based retention mechanism. Therefore, a viral filtration step is commonly utilized in a well-designed recombinant therapeutic protein purification process and is a key component in an overall strategy to minimize the risks of adventitious and endogenous viral particles during the manufacturing of biotechnology products. This review summarizes the history of viral filtration, currently available viral filters and prefilters, and viral filtration integrity test methods and study models. There is also discussion of current understanding and gaps with an eye toward future trends and emerging filtration technologies.

Peer review status:UNDER REVIEW

02 Aug 2021Submitted to Biotechnology and Bioengineering
03 Aug 2021Assigned to Editor
03 Aug 2021Submission Checks Completed
09 Aug 2021Reviewer(s) Assigned
01 Sep 2021Editorial Decision: Revise Major
01 Sep 2021Review(s) Completed, Editorial Evaluation Pending