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Sequential allogenic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive Myeloid Sarcoma and Acute B-Lymphoblastic Leukemia
  • +13
  • Giuliana Rizzuto,
  • Matteo Leoncin,
  • Silvia Imbergamo,
  • Daniela Taurino,
  • Maria Caterina Micò,
  • Manuela Tosi,
  • Anna Michelato,
  • Ksenija Buklijas,
  • Orietta Spinelli,
  • Federico Lussana,
  • Federica Lessi,
  • Marco Pizzi,
  • Laura Bonaldi,
  • Gianni Binotto,
  • Alessandro Rambaldi,
  • Carmela Gurrieri
Giuliana Rizzuto
ASST Papa Giovanni XXIII

Corresponding Author:[email protected]

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Matteo Leoncin
Universita degli Studi di Padova
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Silvia Imbergamo
Universita degli Studi di Padova
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Daniela Taurino
Aziende Socio Sanitarie Territoriale Papa Giovanni XXIII
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Maria Caterina Micò
Azienda Ospedaliera Papa Giovanni XXIII
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Manuela Tosi
Azienda Ospedaliera Papa Giovanni XXIII
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Anna Michelato
Azienda Ospedaliera Papa Giovanni XXIII
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Ksenija Buklijas
Azienda Ospedaliera Papa Giovanni XXIII
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Orietta Spinelli
Azienda Ospedaliera Papa Giovanni XXIII
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Federico Lussana
ASST Papa Giovanni XXIII
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Federica Lessi
Università degli Studi di Padova
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Marco Pizzi
Universita degli Studi di Padova Scuola di Medicina e Chirurgia
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Laura Bonaldi
Istituto Oncologico Veneto Istituto di Ricovero e Cura a Carattere Scientifico
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Gianni Binotto
Università degli Studi di Padova
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Alessandro Rambaldi
University of Milan
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Carmela Gurrieri
Università degli Studi di Padova
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Abstract

The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1-JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here we report an interesting case of PCM1-JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL.
22 Jul 2021Submitted to Clinical Case Reports
22 Jul 2021Submission Checks Completed
22 Jul 2021Assigned to Editor
08 Aug 2021Reviewer(s) Assigned
12 Sep 2021Review(s) Completed, Editorial Evaluation Pending
21 Sep 2021Editorial Decision: Revise Minor
09 Nov 20211st Revision Received
15 Nov 2021Submission Checks Completed
15 Nov 2021Assigned to Editor
15 Nov 2021Review(s) Completed, Editorial Evaluation Pending
01 Dec 2021Editorial Decision: Accept