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Sequential allogenic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive Myeloid Sarcoma and Acute B-Lymphoblastic Leukemia
  • +13
  • Giuliana Rizzuto,
  • Matteo Leoncin,
  • Silvia Imbergamo,
  • Daniela Taurino,
  • Maria Caterina Micò,
  • Manuela Tosi,
  • Anna Michelato,
  • Ksenija Buklijas,
  • Orietta Spinelli,
  • Federico Lussana,
  • Federica Lessi,
  • Marco Pizzi,
  • Laura Bonaldi,
  • Gianni Binotto,
  • Alessandro Rambaldi,
  • Carmela Gurrieri
Giuliana Rizzuto
ASST Papa Giovanni XXIII
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Matteo Leoncin
Universita degli Studi di Padova
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Silvia Imbergamo
Universita degli Studi di Padova
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Daniela Taurino
Aziende Socio Sanitarie Territoriale Papa Giovanni XXIII
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Maria Caterina Micò
Azienda Ospedaliera Papa Giovanni XXIII
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Manuela Tosi
Azienda Ospedaliera Papa Giovanni XXIII
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Anna Michelato
Azienda Ospedaliera Papa Giovanni XXIII
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Ksenija Buklijas
Azienda Ospedaliera Papa Giovanni XXIII
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Orietta Spinelli
Azienda Ospedaliera Papa Giovanni XXIII
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Federico Lussana
ASST Papa Giovanni XXIII
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Federica Lessi
Università degli Studi di Padova
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Marco Pizzi
Universita degli Studi di Padova Scuola di Medicina e Chirurgia
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Laura Bonaldi
Istituto Oncologico Veneto Istituto di Ricovero e Cura a Carattere Scientifico
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Gianni Binotto
Università degli Studi di Padova
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Alessandro Rambaldi
University of Milan
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Carmela Gurrieri
Università degli Studi di Padova
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Abstract

The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1-JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here we report an interesting case of PCM1-JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL.

Peer review status:UNDER REVIEW

22 Jul 2021Submitted to Clinical Case Reports
22 Jul 2021Assigned to Editor
22 Jul 2021Submission Checks Completed
08 Aug 2021Reviewer(s) Assigned
12 Sep 2021Review(s) Completed, Editorial Evaluation Pending