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Hemophagocytic Lymphohistiocytosis/Macrophage-Activation Syndrome (HLH/MAS) Following Treatment with Tisagenlecleucel
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  • Reyes Maria Martin-Rojas,
  • Ignacio Gomez-Centurion,
  • Rebeca Bailen,
  • Mariana Bastos,
  • Francisco Diaz-Crespo,
  • Diego Carbonell,
  • Rafael Correa-Rocha,
  • Marjorie Pion,
  • Cristina Muñoz,
  • Milagros Sancho,
  • Isabel Gomez-Fernandez,
  • Gillen Oarbeascoa,
  • Ana Perez-Corral,
  • Carolina Martinez-Laperche,
  • Javier Anguita,
  • Ismael Buño,
  • Javier Menarguez,
  • Jose Luis Diez-Martin,
  • Mi Kwon
Reyes Maria Martin-Rojas
Hospital General Universitario Gregorio Marañón
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Ignacio Gomez-Centurion
Hospital General Universitario Gregorio Marañón
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Rebeca Bailen
Hospital General Universitario Gregorio Marañón
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Mariana Bastos
Hospital General Universitario Gregorio Marañón
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Francisco Diaz-Crespo
Hospital General Universitario Gregorio Marañón
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Diego Carbonell
Hospital General Universitario Gregorio Marañón
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Rafael Correa-Rocha
Instituto de Investigación Sanitaria Gregorio Marañón
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Marjorie Pion
Instituto de Investigación Sanitaria Gregorio Marañón
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Cristina Muñoz
Hospital General Universitario Gregorio Marañón
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Milagros Sancho
Hospital General Universitario Gregorio Marañón
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Isabel Gomez-Fernandez
Hospital General Universitario Gregorio Marañón
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Gillen Oarbeascoa
Hospital General Universitario Gregorio Marañón
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Ana Perez-Corral
Hospital General Universitario Gregorio Marañón
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Carolina Martinez-Laperche
Hospital General Universitario Gregorio Marañón
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Javier Anguita
Hospital General Universitario Gregorio Marañón
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Ismael Buño
Hospital General Universitario Gregorio Marañón
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Javier Menarguez
Hospital General Universitario Gregorio Marañón
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Jose Luis Diez-Martin
Hospital General Universitario Gregorio Marañón
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Mi Kwon
Hospital General Universitario Gregorio Maranon
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Abstract

CAR-T cell related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with high mortality rates and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the combination of several techniques for CAR-T cell follow-up, allows a more precise management of this complication.

Peer review status:IN REVISION

28 Jul 2021Submitted to Clinical Case Reports
29 Jul 2021Assigned to Editor
29 Jul 2021Submission Checks Completed
08 Aug 2021Reviewer(s) Assigned
09 Sep 2021Review(s) Completed, Editorial Evaluation Pending
10 Sep 2021Editorial Decision: Revise Minor