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Challenge of Interpreting Cytoplasmic CD20 Stain in Diffuse Large B Cell Lymphoma Biopsy Specimen of Patients with Steroid Usage
  • Jui Choudhuri,
  • Yang Shi,
  • Yanhua Wang
Jui Choudhuri
Montefiore Medical Center
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Yang Shi
Montefiore Medical Center
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Yanhua Wang
Montefiore Hospital and Medical Center
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Abstract

Lymphoma work-up involves immunohistochemical stains to help reach the diagnosis. It is imperative to have clinical information and sound knowledge of staining pattern of antibodies to avoid misinterpretation of results. We describe two cases in which pre-biopsy steroid hindered antigenic profile, leading to “cytoplasmic granular staining” and causing delay.

Peer review status:UNDER REVIEW

12 Jul 2021Submitted to Clinical Case Reports
13 Jul 2021Assigned to Editor
13 Jul 2021Submission Checks Completed
08 Aug 2021Reviewer(s) Assigned