loading page

Pharmacokinetics of Dantrolene in the CVVH/PE Treatment of Malignant Hyperthermia in a 14-year-old Chinese Boy: A Case Report and Literature Review
  • +6
  • Xiao-Xiao LI,
  • Chao Li,
  • Yang Zhou,
  • Xin Xiong,
  • Chuhui Wang,
  • Congya Zhou,
  • Bin Han,
  • Li Yang,
  • Xiangyang Guo
Xiao-Xiao LI

Corresponding Author:[email protected]

Author Profile
Chao Li
Peking University Third Hospital
Author Profile
Yang Zhou
Peking University Third Hospital
Author Profile
Xin Xiong
Peking University Third Hospital
Author Profile
Chuhui Wang
Peking University Third Hospital
Author Profile
Congya Zhou
Peking University Third Hospital
Author Profile
Bin Han
Peking University Third Hospital
Author Profile
Li Yang
Peking University Third Hospital
Author Profile
Xiangyang Guo
Peking University Third Hospital
Author Profile

Abstract

Malignant hyperthermia (MH) is a rare life-threatening response that triggered by exposure to specific anesthetics commonly used during surgery interventions. Dantrolene is a well-known drug which used as first-line therapy for MH. A 14-year-old Chinese boy with a mutation in RYR1 whose muscle biopsy diagnosis was central core disease (CCD) occurred MH after cervical spine surgery underwent general anesthesia without volatile anesthetics or succinylcholine. The MH crisis treatment workflow was started and intravenous dantrolene was used soon which combined with sequent continuous veno-venous hemofiltration (CVVH) and plasma exchange (PE) therapy. We explored the pharmacokinetics of dantrolene during the treatment and the results showed that a one-compartment model with first-order absorption and elimination was sufficient to characterize dantrolene pharmacokinetics. The clearance estimate for dantrolene was 0.43 mL/(min*kg) and volume of distribution was 0.61 L/kg. The clearance of dantrolene was significantly affected by CVVH and PE.