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Pharmacogenomic alerts: developing guidance for use by healthcare professionals
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  • John-Paul Carter,
  • James Critchlow,
  • Sarah Jackson,
  • Sonali Sanghvi,
  • Helene Feger,
  • Afzal Chaudhry,
  • Lorraine Foley,
John-Paul Carter

Corresponding Author:[email protected]

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James Critchlow
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Sarah Jackson
Professional Record Standards Body
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Sonali Sanghvi
NHS England and NHS Improvement London
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Helene Feger
Professional record standards body
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Afzal Chaudhry
Cambridge University Hospitals NHS Foundation Trust
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Lorraine Foley
Professional Record Standards Body
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University College London
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Background: For diseases with a genetic cause genomics can deliver improved diagnostics and facilitate access to targeted treatments. Drug pharmacodynamics and pharmacokinetics are often dependent on genetic variation underlying these processes. As pharmacogenomics comes of age it may be the first way in which genomics is utilised at a population level. Still required is guidance and standards of how genomic information can be communicated within the health record, and how clinicians should be alerted to variation impacting the use of medicines. Methods: The Professional Record Standards Body commissioned by National Health Service England developed guidance on using pharmacogenomics information in clinical practice. We conducted research with those implementing pharmacogenomics in England and internationally to produce guidance and recommendations for a systems-based approach. Results: A consensus viewpoint is that systems need to be in place to ensure the safe provision of pharmacogenomics information that is curated, actionable and up-to-date. Standards should be established with respect to notification and information exchange, which could impact new or existing prescribing and these must be in keeping with routine practice. Alerting systems should contribute to safer practices. Conclusion: Ensuring pharmacogenetics information is available to make use of medicines safer will require major effort of which this guidance is a beginning. Standards are required to ensure useful genomic information within the health record can be communicated to clinicians in the right format and times to be actioned successfully. A multidisciplinary group of stakeholders must be engaged in developing pharmacogenomic standards to support the most appropriate prescribing.
30 Jul 2021Submitted to British Journal of Clinical Pharmacology
02 Aug 2021Submission Checks Completed
02 Aug 2021Assigned to Editor
05 Aug 2021Reviewer(s) Assigned
20 Aug 2021Review(s) Completed, Editorial Evaluation Pending
02 Sep 2021Editorial Decision: Revise Major
29 Nov 20211st Revision Received
07 Dec 2021Submission Checks Completed
07 Dec 2021Assigned to Editor
07 Dec 2021Review(s) Completed, Editorial Evaluation Pending
14 Dec 2021Reviewer(s) Assigned
31 Dec 2021Editorial Decision: Accept
Jul 2022Published in British Journal of Clinical Pharmacology volume 88 issue 7 on pages 3201-3210. 10.1111/bcp.15234