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In-Hospital Respiratory Viral Infections for Patients with Established BPD in the SARS-CoV-2 Era
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  • Matthew Kielt,
  • Angela Murphy,
  • Jodi Smathers,
  • Maleah Bates,
  • Leif Nelin,
  • Edward Shepherd
Matthew Kielt
Nationwide Children's Hospital
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Angela Murphy
Nationwide Children's Hospital
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Jodi Smathers
Nationwide Children's Hospital
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Maleah Bates
Nationwide Children's Hospital
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Leif Nelin
Nationwide Children's Hospital
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Edward Shepherd
Nationwide Childrens Hospital
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Abstract

Objective Our objective was to test the hypothesis that in-hospital respiratory viral infections (RVI) would be significantly lower in a cohort of patients with established bronchopulmonary dysplasia in the SARS-CoV-2 era when compared to historical controls. Study Design On April 1, 2020, we implemented a universal infection prevention bundle to minimize the risk of nosocomial SARS-CoV-2 transmission in a dedicated BPD intensive care unit. We performed a retrospective cohort study and included patients with established BPD, as defined by the 2019 Neonatal Research Network criteria, admitted to our center who underwent real-time polymerase-chain-reaction RVI testing between January 1, 2015 and March 31, 2021. We excluded patients re-admitted from home. We compared to number of tests performed, the proportion of positive tests, and the distribution of viral respiratory pathogens in the pre- and post-SARS-CoV-2 eras. Results Among 176 patients included in the sudy, 663 RVI tests were performed and 172 (26%) tests were positive. The median number of tests performed, measured in tests per patient per month, in the SARS-CoV-2 era was not significantly different compared to the pre-SARS-CoV-2 era (0.45 vs 0.34 tests per patient per month, P = 0.07). The proportion of positive RVI tests was significantly lower in the SARS-CoV-2 era when compared to the pre-SARS-CoV-2 era (0.06 vs 0.30, P<0.0001). No patients tested positive for SARS-CoV-2 in the SARS-CoV-2 era. Conclusions Infection prevention measures developed in response to the SARS-CoV-2 pandemic may reduce the risk of RVIs in hospitalized patients with established BPD.

Peer review status:ACCEPTED

30 Jul 2021Submitted to Pediatric Pulmonology
03 Aug 2021Submission Checks Completed
03 Aug 2021Assigned to Editor
03 Aug 2021Reviewer(s) Assigned
28 Aug 2021Review(s) Completed, Editorial Evaluation Pending
29 Aug 2021Editorial Decision: Revise Major
13 Sep 20211st Revision Received
14 Sep 2021Submission Checks Completed
14 Sep 2021Assigned to Editor
14 Sep 2021Reviewer(s) Assigned
24 Sep 2021Review(s) Completed, Editorial Evaluation Pending
24 Sep 2021Editorial Decision: Accept