Abstract
Aims Primary hyperparathyroidism (PHPT) is common disorder in which
parathyroid hormone (PTH) is excessively secreted from one or more of
four parathyroid glands. Primary hyperparathyroidism (PHPT) is an
endocrinological disorder associated with increased systemic
inflammation, endothelial dysfunction. The systemic inflammation may
cause subclinical decrease in cardiac function. Our aim in our study is
to compare the markers of systemic inflammation in preoperative,
postoperative period with PHPT, to show that PDW (platelet distribution
width) value may be a predictive value for the development of
cardiovascular (CVO), thromboembolic events (TBO) in patients with
primary hyperparathyroidism. Results In this study, patients who
underwent parathyroidectomy for primary hyperparathyroidism between 2014
- 2021 were retrospectively screened. A total of 56 patients who
underwent parathyroidectomy for PHPT were included in the study. In
addition to demographic and clinical information; PTH, corrected
calcium, phosphate, white blood cell (WBC) count, platelet counts and
PDW of the patients were recorded before and three months after
parathyroidectomy. Systemic inflammatory index (SII) was calculated
according to appropriate formula. Discussion The preoperative PDW value
of the patients was found to be significantly higher when compared with
the postoperative period and control groups. Preoperative platelet
value, on the other hand, was statistically significantly higher when
compared with control group. PDW values were found to be statistically
significantly decreased in the postoperative period compared to the
preoperative period in patients. Conclusion Increased PDW value before
parathyroidectomy may be a predictive value of inflammatıon and the
development of CVO ,TBO. Keywords: primary hyperparathyroidism, PDW
(platelet distribution width), platelets, parathyroidectomy It is known
to cause subclinical inflammation and subclinical cardiac dysfunction in
primary hyperparathyroidism. There are conflicting studies on
inflammation markers. Our article is the first to study PDW in primary
hyperparathyroidism. High preoperative PDW indicates that PHPT may be a
risk factor for cardiovascular events.