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Autoimmune Overload: An atypical presentation of granulomatosis with polyangiitis in an adolescent with type-1 diabetes mellitus
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  • Jaimie Wardinger,
  • Lauren Sussman,
  • Breann Litwa,
  • Elizabeth Irish,
  • Llewellyn Foulke,
  • Robert Kaslovsky
Jaimie Wardinger
Albany Medical Center
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Lauren Sussman
Albany Medical Center
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Breann Litwa
Albany Medical College
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Elizabeth Irish
Albany Medical College
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Llewellyn Foulke
Albany Medical Center
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Robert Kaslovsky
Albany Medical College
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Abstract

We report a case of granulomatosis with polyangiitis (GPA) in a pediatric patient with a history of type 1 diabetes mellitus (T1DM) after a somewhat unusual presentation. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a relatively rare entity in the general population, and are even less common amongst the pediatric population. Our patient’s chronic history of vague and systemic symptoms paired with social and environmental stressors contributed to her convoluted picture and late diagnosis. In addition, her T1DM adds an interesting element to her case, begging the question of whether her propensity for autoimmune conditions played a role in the development of this disease. With this case, we hope to increase clinician level of suspicion and promote early diagnosis and treatment for future pediatric patients.

Peer review status:UNDER REVIEW

18 Jul 2021Submitted to Pediatric Pulmonology
20 Jul 2021Submission Checks Completed
20 Jul 2021Assigned to Editor
31 Jul 2021Reviewer(s) Assigned
12 Aug 2021Review(s) Completed, Editorial Evaluation Pending
13 Aug 2021Editorial Decision: Revise Minor
11 Sep 20211st Revision Received
13 Sep 2021Submission Checks Completed
13 Sep 2021Assigned to Editor
13 Sep 2021Reviewer(s) Assigned
22 Sep 2021Review(s) Completed, Editorial Evaluation Pending