Association between serum sST2 levels and CD4+T cells in patients with
organ failure: a pilot study
Background: The importance of sST2 has been increasingly appreciated
because of its associated with the development of heart failure and
related diseases. Objective: The aim of this study was to evaluate the
association of sST2 with CD4+T cells in patients with organ failure.
Methods: 100 (M:F=60:40) organ failure patients aged
(mean±SD=69.08±16.68) and 30 (M:F=14:16) normal control aged
(mean±SD=60.23±13.99) serum sST2 were detected by chemiluminescence
assay (CLIA) and the expression of serum IL-1, IL-6 and TNF-α were
analyzed by enzyme-linked immunosorbent assay (ELISA). The proportion of
CD4+T cells in peripheral blood was determined by flow cytometry (FCM).
Association of sST2 with CD4+T cells in organ failure patents were
analyzed by SPASS. Results: The expression of sST2 in organ failure
patients (107.4±5.79ng/mL) was significantly higher than normal control
(8.57±0.35ng/mL). Inflammatory factors IL-1 and IL-6 in patients were
also increased than normal controls (IL-1: 0.33±0.04pg/mL vs
0.14±0.02pg/mL. IL-6: 165.7±10.53pg/mL vs 95.33±7.42pg/mL. TNF-α:
1.57±0.14pg/mL vs 6.11±0.77pg/mL). In patients, the results showed CD4+T
cells were reduced compare with normal control (238.3±13.67/μL vs
1081±39.13/μL). Additionally, sST2 was found to be inversely associated
with CD4+T cell in patients with organ failure. Conclusion: sST2 level
was closely related to the development of organ failure and sST2 was
obviously correlated with CD4+T cell in patients with organ failure.