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SARS-COV-2 Vaccines Immunological Impact
  • Hatem Tallima,
  • Rashika El Ridi
Hatem Tallima
Department of Chemistry, School of Science and Engineering, American University, Zoology Department, Faculty of Science, Cairo University
Rashika El Ridi
Zoology Department, Faculty of Science, Cairo University


The immune responses to SARS-CoV-2 are herein detailed to clarify the innate immunity protective effects in a large fraction of individuals exposed to the infection, and the drawbacks of the interference of the acquired immunity cytotoxic T cells and antibody-dependent natural killer cell-mediated cytotoxicity arms. Very precisely, the available vaccines based on full-length spike glycoprotein in a mRNA or DNA-based construct, or whole virus potently lead to generation of these immunologically damaging effectors, especially following exposure to the pathogen. Conversely, a vaccine exclusively based on spike glycoprotein subunit 1 in a protein form can protect against the life-threatening virus infection and never lead to adverse side effects.