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Post-Operative Ileus: a Pharmacological Perspective
  • Etienne Buscail,
  • Celine Deraison
Etienne Buscail
University Hospital Centre Toulouse
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Celine Deraison
Inserm U1220
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Abstract

Post-operative ileus (POI) is a frequent complication after abdominal surgery. The consequences of POI can be potentially serious such as bronchial inhalation or acute functional renal failure. Numerous advances in peri-operative management, particularly early rehabilitation, have made it possible to decrease POI. Despite this, the rate of prolonged POI ileus remains high and can be as high as 25% of patients in colorectal surgery. From a pathophysiological point of view, POI has two phases, an early neurological phase and a later inflammatory phase, to which we could add a “pharmacological” phase during which analgesic drugs, particularly opiates, play a central role. The aim of this review article is to describe the phases of the pathophysiology of POI, to analyse the pharmacological treatments currently available through published clinical trials and finally to discuss the different research areas for potential pharmacological targets.

Peer review status:UNDER REVIEW

20 Jul 2021Submitted to British Journal of Pharmacology
21 Jul 2021Assigned to Editor
21 Jul 2021Submission Checks Completed
26 Jul 2021Reviewer(s) Assigned