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Effect of Routine Thromboprophylaxis with Low Molecular Weight Heparin in Hospitalized Covid-19 Patients
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  • Tolga Demir,
  • Macit Bitargil,
  • Helin El Kilic,
  • Hakki Kursat Cetin,
  • Nilufer Bektas,
  • Begum Ozuekren Kasapoglu,
  • Kudret Keskin,
  • Mutlu Cagan Sumerkan,
  • Ozgur Selim Ser,
  • Hale Bolgi Demir,
  • Ahmet Ibrahim Balkaya,
  • Ulku Turkmen,
  • Sultan Acar,
  • Nermin Balta Başı,
  • Dilek Yildiz Sevgi,
  • Ahsen Oncul,
  • Mehdi Zengin,
  • Birol Kabakci,
  • Ömer Alyan,
  • Ayse Surhan Cinar,
  • Ilyas Dokmetas,
  • Ismail Koramaz,
  • Haci Mustafa Ozdemir
Tolga Demir
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Macit Bitargil
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Helin El Kilic
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Hakki Kursat Cetin
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Nilufer Bektas
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Begum Ozuekren Kasapoglu
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Kudret Keskin
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Mutlu Cagan Sumerkan
University of Health Sciences, Sisli Hamidiye Etfal Teaching and Research Hospital
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Ozgur Selim Ser
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Hale Bolgi Demir
University of Health Sciences, Gaziosmanpasa Training and Research Hospital
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Ahmet Ibrahim Balkaya
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Ulku Turkmen
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Sultan Acar
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Nermin Balta Başı
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Dilek Yildiz Sevgi
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Ahsen Oncul
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Mehdi Zengin
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Birol Kabakci
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Ömer Alyan
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Ayse Surhan Cinar
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Ilyas Dokmetas
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Ismail Koramaz
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital
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Haci Mustafa Ozdemir
University of Health Sciences, Sisli Hamidiye Etfal Teaching and Research Hospital
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Abstract

Background: Coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy presented with venous thromboembolism and arterial thromboses. The aim of this study was to evaluate the effect of routine thromboprophylaxis with low molecular weight heparin (LMWH) on clinical outcomes including mortality and need for intensive care unit (ICU) admission in hospitalized COVID-19 patients. Methods: All confirmed patients with COVID-19 hospitalized to COVID-19 dedicated wards, from March 15 to May 15, 2020, were included in this retrospective cohort study. Two groups of patients were established, according to the non-routine and routine application of LMWH with therapeutic, weight-based, anticoagulation dosing. Clinical, laboratory and treatment data were collected, analyzed and compared between the two groups. A logistic regression model was developed to assess the factors related to in-hospital adverse outcomes. Results: A total of 1511 patients (797 men, median age 59.0 years) were retrospectively analyzed (Group non-routine LMWH (n=828); group routine LMWH (n=683)). Multivariate logistic regression analysis showed routine use of LMWH, favipiravir administration, extreme values of WBC count, NLR, and troponin I as factors independently associated with in-hospital adverse outcomes (OR=0.25, 95% CI: 0.83-0.91; p<0.001 for routine use of LMWH). Conclusion: Routine thromboprophylaxis with LMWH reduced mortality and ICU admission in patients admitted with COVID-19 infection.