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Thiol levels in mild or moderate covid-19 patients: A comparison of variant and classic covid-19 cases
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  • Basri Furkan Dağcıoğlu,
  • Ahmet Keskin,
  • Rahmet Güner,
  • Ayse Kaya Kalem,
  • FATMA ESER,
  • Özcan Erel,
  • Salim Neselioglu,
  • Fatma Bayrakdar,
  • Adem ÖZKARA
Basri Furkan Dağcıoğlu
Ankara Yildirim Beyazit University
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Ahmet Keskin
Yildirim Beyazit University Faculty of Medicine
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Rahmet Güner
Ankara Yildirim Beyazit University Faculty of Medicine
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Ayse Kaya Kalem
Ankara Yildirim Beyazit University Faculty of Medicine
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FATMA ESER
Ankara Yildirim Beyazit University Faculty of Medicine
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Özcan Erel
Ankara Yildirim Beyazit University
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Salim Neselioglu
Yildirim Beyazit University Faculty of Medicine
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Fatma Bayrakdar
Public Health Institutions of Turkey, Ankara, Turkey.
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Adem ÖZKARA
Ankara City Hospital
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Abstract

Background: Various variants of the covid-19 have started to attract attention recently. The clinical course of these variants and possible predictive parameters are being investigated. This study aimed to examine the relationship between thiol levels, which are indicators of oxidative stress, and variant covid-19 types. Methods: In this cross-sectional study, patients with a diagnosis of classic covid-19 and patients with a diagnosis of variant covid-19 with mild and moderate symptoms followed in the clinical observatory of Ankara city hospital were included in the study group. The patients were divided into two groups according to the covid-19 type as variant and classic covid-19, and a healthy control group is added for comparison. A complete blood count and thiol analysis are performed from the venous blood samples. Obtained results were compared between groups, and the ROC analysis is performed. Results: Thiol levels were significantly lower in patients with a diagnosis of Covid-19 compared to the control group. In terms of WBC, lymphocyte, neutrophil, NLR, ferritin and thiol parameters, patients with variant covid-19 differed significantly from patients with a classic covid-19 diagnosis. Thiol levels’ cut-off values to distinguish between variant covid-19 patients and control group from classical covid-19 patients were almost identical (423 and 422 µmol/L, respectively). Conclusions: It seems possible to use thiol as a sensitive, specific and cost-effective marker to suspect variant covid-19 cases. Since this study is probably the first example in this subject, it would form a basis for further studies. Keywords: Covid-19, SARS-CoV-2, variant covid-19, thiol, oxidative stress.

Peer review status:ACCEPTED

22 Jun 2021Submitted to International Journal of Clinical Practice
24 Jun 2021Submission Checks Completed
24 Jun 2021Assigned to Editor
22 Jul 2021Reviewer(s) Assigned
06 Aug 2021Review(s) Completed, Editorial Evaluation Pending
09 Aug 2021Editorial Decision: Revise Major
15 Aug 20211st Revision Received
18 Aug 2021Submission Checks Completed
18 Aug 2021Assigned to Editor
18 Aug 2021Review(s) Completed, Editorial Evaluation Pending
22 Aug 2021Editorial Decision: Accept