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Pooled molecular occurrence of Mycoplasma gallisepticum and Mycoplasma synoviae in poultry: A systematic review and meta-analysis
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  • Miguel Angel Chaidez-Ibarra,
  • Diana Zuleika Velazquez,
  • Idalia Enriquez-Verdugo,
  • Nohemi Castro del Campo,
  • Miguel Angel Rodriguez-Gaxiola,
  • Arnulfo Montero-Pardo,
  • Daniel Diaz,
  • Soila Maribel Gaxiola
Miguel Angel Chaidez-Ibarra
Universidad Autonoma de Sinaloa
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Diana Zuleika Velazquez
Universidad Autonoma de Sinaloa
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Idalia Enriquez-Verdugo
Universidad Autonoma de Sinaloa
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Nohemi Castro del Campo
Universidad Autonoma de Sinaloa
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Miguel Angel Rodriguez-Gaxiola
Universidad Autonoma de Sinaloa
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Arnulfo Montero-Pardo
Universidad Autonoma de Sinaloa
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Daniel Diaz
Universidad Autonoma de Sinaloa
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Soila Maribel Gaxiola
Universidad Autonoma de Sinaloa
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Abstract

Worldwide, Mycoplasma gallisepticum (MG) and M. synoviae (MS) are the main agents responsible for chronic respiratory disease in poultry. Therefore, we conducted a systematic review and meta-analysis to estimate their occurrence. We searched electronic databases to find peer-reviewed publications reporting the molecular detection of MG and MS in poultry and used meta-analysis to estimate their pooled occurrence (combined flock and individual), aggregating results at the regional and national levels. We performed a subgroup meta-analysis for subpopulations (broilers, layers, breeders, and diverse poultry including turkeys, ducks, and ostriches) and used meta-regression with categorical modifiers. We retrieved 2,294 publications from six electronic databases and included 85 publications from 33 countries that reported 62 studies with 22,162 samples for MG and 48 studies with 26,413 samples for MS. The pooled occurrence was 38.4% (95% CI: 23.5-54.5) for MS and 27.0% (20.4-34.2) for MG. Among regions, Europe and Central Asia had the lowest occurrence for both pathogens, while MG and MS were highly prevalent in South Asia and sub-Saharan Africa, respectively. MG occurrence was higher in Algeria, Saudi Arabia, and Sudan, whereas China, Egypt, and Ethiopia reported a higher occurrence of MS. MS and MG were more prevalent in the breeders and layers (62.6% and 31.2%, respectively) than in diverse poultry. The year of publication, the sample size, and the level of ambient air pollution (measured indirectly by PM2.5) were associated with the occurrence of both mycoplasmas. Our study revealed a high and heterogeneous occurrence of MG and MS and justifies the need for an early detection and improved control measures to reduce the spread of these pathogens.

Peer review status:ACCEPTED

20 Jul 2021Submitted to Transboundary and Emerging Diseases
20 Jul 2021Submission Checks Completed
20 Jul 2021Assigned to Editor
21 Jul 2021Reviewer(s) Assigned
09 Aug 2021Review(s) Completed, Editorial Evaluation Pending
10 Aug 2021Editorial Decision: Revise Minor
12 Aug 20211st Revision Received
12 Aug 2021Submission Checks Completed
12 Aug 2021Assigned to Editor
12 Aug 2021Reviewer(s) Assigned
23 Aug 2021Review(s) Completed, Editorial Evaluation Pending
23 Aug 2021Editorial Decision: Accept