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Laboratory parameters between multisystem inflammatory syndrome in children and Kawasaki disease
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  • Chunling Zhou,
  • Yan Zhao,
  • Xia Wang,
  • Ying Huang,
  • Xuewen Tang,
  • Lei Tang
Chunling Zhou
People's Hospital of Chongqing Banan District
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Yan Zhao
People's Hospital of Chongqing Banan District
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Xia Wang
Chongqing Youyoubaobei Women and Children's Hospital
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Ying Huang
Chongqing medical university affiliated children's hospital
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Xuewen Tang
People's Hospital of Chongqing Banan District
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Lei Tang
People's Hospital of Chongqing Banan District
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Abstract

Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) has been described to partially overlap with Kawasaki disease (KD) with regard to clinical symptoms, but they are unlikely to share the same disease entity. We conducted a systematic review and meta-analysis to characterize the laboratory parameters of MIS-C compared with those of KD and Kawasaki disease shock syndrome (KDSS). Databases were searched for studies on laboratory parameters of MIS-C (hematology, inflammatory markers, cardiac markers and biochemistry) through May 31, 2021. Twelve studies with 3073 participants yielded 969 MIS-C patients. In terms of hematology, MIS-C patients had lower levels of leukocytes, absolute lymphocyte count and platelet count (PLT) than KD patients and had similar absolute neutrophil count (ANC) and hemoglobin (Hb) levels. In terms of inflammatory markers, MIS-C patients had higher levels of C-reactive protein, D-dimer and ferritin than KD patients and had similar levels of procalcitonin and ESR. In terms of cardiac markers, MIS-C patients had higher CPK levels than KD patients. The levels of NT-proBNP, troponin and AST were not significantly different between MIS-C and KD patients. In terms of biochemistry, MIS-C patients had lower levels of albumin, sodium and ALT and higher levels of creatinine than KD patients. In addition, MIS-C patients had lower levels of PLT, Hb and ESR and higher levels of ANC than KDSS patients. Measurement of laboratory parameters might assist clinicians with accurate evaluation of MIS-C and further mechanistic research.

Peer review status:ACCEPTED

14 Jul 2021Submitted to Pediatric Pulmonology
15 Jul 2021Submission Checks Completed
15 Jul 2021Assigned to Editor
18 Jul 2021Reviewer(s) Assigned
13 Aug 2021Review(s) Completed, Editorial Evaluation Pending
13 Aug 2021Editorial Decision: Revise Major
26 Aug 20211st Revision Received
26 Aug 2021Submission Checks Completed
26 Aug 2021Assigned to Editor
26 Aug 2021Reviewer(s) Assigned
17 Sep 2021Review(s) Completed, Editorial Evaluation Pending
19 Sep 2021Editorial Decision: Accept