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Comparison of BK Virus Nephropathy Risk Between Double-J-Stent with Anti-Reflux Mechanism and Standart Double-J-Stent: Single-Center Experience
  • +2
  • nurettin ay,
  • Ramazan Danis,
  • seyhmus kaya,
  • mehtap akbalik kaya,
  • aysel taktak
nurettin ay
Diyarbakir Gazi Yasargil Training and Research Hospital
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Ramazan Danis
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seyhmus kaya
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mehtap akbalik kaya
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aysel taktak
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Abstract

Objectives: Ureteral stend use is a risk factor for BK nephropathy (BKVN). In 2015, we compared the patients with anti-reflux mechanism DJS (ARD-DJS) and those used standard DJS (st-DJS) in terms of BKV and BKVN frequency in 90 kidney transplant patients in two centers. With the increase in the number of our patients over time and lengthening of the follow-up duration, we needed to re-evaluate the data in one center. Materials and Methods: We retrospectively evaluated 211 patients who underwent kidney transplantation at Diyarbakır Gazi Yaşargil Training and Research Hospital between September 2012 and September 2019. The following parameters were recorded, demographic data, immunosuppression protocols, presence of rejection, graft loss, plasma BKV levels, and presence of BKVN. Median and IQR follow-up time for ARD-DJS and St-DJS patients was 72 months (62,5-80,3 months) and 27,8 months (17,4-39,6 months) respectively. Results: Thirteen patients (6,1%) had BKV viremia. BKVN was revealed by kidney biopsy in 3 of 13 patients. However, graft loss due to BKVN was observed in only one patient. ARD-DJS was used in 4 of these cases and standard DJS was used in 9 of these cases. Patients in whom BKV revealed in the first 3 months were compared in the aspect of DJS technique, BKV was significantly less observed in the ARD-DJS group (ARD-DJS: 2 patients; St-DJS:9 patients), (p=0,046). Conclusions: In our study, BKV was observed less in patients with ARD-DJS that were clinically significant but not statistically significant. Therefore, prospective randomized studies with high patient numbers are needed to determine the effectiveness of ARD-DJS.

Peer review status:UNDER REVIEW

20 Jun 2021Submitted to International Journal of Clinical Practice
21 Jun 2021Assigned to Editor
21 Jun 2021Submission Checks Completed
17 Jul 2021Reviewer(s) Assigned