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COVID-19 and rhinovirus in pediatric: are there differences in clinical presentation and outcomes?
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  • Maria Fernanda Pereira,
  • Priscila Suguita,
  • Nadia Litvinov,
  • Sylvia Farhat,
  • Carolina Lazari,
  • Juliana Framil,
  • Camila Paula,
  • Pedro Bedê,
  • Catarina Bueno,
  • Priscila Branas,
  • Irina Guimarães,
  • Emilly dos Santos,
  • Marcia Leite,
  • Ana Navega,
  • Danilo Nanbu,
  • Claudio Schvartsman,
  • Thelma Okay,
  • João Pinho,
  • clovis da silva,
  • Heloisa Marques
Maria Fernanda Pereira
Universidade de São Paulo Instituto da Criança
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Priscila Suguita
Universidade de São Paulo Instituto da Criança
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Nadia Litvinov
Universidade de São Paulo Instituto da Criança
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Sylvia Farhat
Universidade de São Paulo Instituto da Criança
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Carolina Lazari
Universidade de São Paulo Instituto da Criança
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Juliana Framil
Universidade de São Paulo Instituto da Criança
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Camila Paula
Universidade de São Paulo Instituto da Criança
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Pedro Bedê
Universidade de São Paulo Instituto da Criança
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Catarina Bueno
Universidade de São Paulo Instituto da Criança
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Priscila Branas
Universidade de São Paulo Instituto da Criança
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Irina Guimarães
Universidade de São Paulo Instituto da Criança
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Emilly dos Santos
Universidade de Sao Paulo Instituto de Medicina Tropical de Sao Paulo
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Marcia Leite
Universidade de São Paulo Instituto da Criança
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Ana Navega
Universidade de São Paulo Instituto da Criança
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Danilo Nanbu
Universidade de São Paulo Instituto da Criança
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Claudio Schvartsman
Universidade de São Paulo Instituto da Criança
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Thelma Okay
Universidade de São Paulo Instituto de Medicina Tropical de São Paulo
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João Pinho
Universidade de São Paulo Instituto da Criança
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clovis da silva
Universidade de Sao Paulo Faculdade de Medicina
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Heloisa Marques
Universidade de São Paulo Instituto da Criança
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Abstract

The dynamic of SARS-CoV-2 and other respiratory virus in children and adolescents is relevant in clinical context. There are few studies comparing clinical course in COVID-19 (coronavirus disease) and other respiratory virus in pediatric patients. The aim of this study was to compare demographics and clinical features, exams abnormalities, and outcomes in SARS-CoV-2 and other respiratory virus infections in a pediatric population. This was a single-center prospective study, between April 17 to September 30, 2020. We evaluated 76 pediatric COVID-19 and 157 other respiratory virus infections. Rhinovirus occurred in 132/157(84%). COVID-19 patients were significantly older, had more fever (69% versus 50%; p=0.01), pneumonia (22% versus 5%; p<0.01), myalgia (29% versus 8%; p=0.001), headache (31% versus 14%; p=0.01) and worse outcomes than those with other respiratory virus infections. Our data emphasizes differences in clinical presentation and outcomes between pediatric COVID-19 and rhinovirus infections.