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Drugs For Attenuation of Hemodynamic Responses In Patients Undergoing Elective Off-Pump Coronary Artery Bypass Graft: A Randomized Clinical Trial
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  • NAYELY GARCIA MENDEZ,
  • Guillermo Careaga Reyna,
  • Marisol Jiménez Ramírez,
  • Ramón Campos Duran,
  • Carlos Manterola Delgado,
  • Ruben Mejia Bravo
NAYELY GARCIA MENDEZ
Universidad de La Frontera
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Guillermo Careaga Reyna
Instituto Mexicano del Seguro Social
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Marisol Jiménez Ramírez
Instituto Mexicano del Seguro Social
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Ramón Campos Duran
Instituto Mexicano del Seguro Social
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Carlos Manterola Delgado
Universidad de La Frontera
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Ruben Mejia Bravo
Instituto Mexicano del Seguro Social
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Abstract

Objective: We aimed to compare the effectiveness of esmolol (ESM) vs. dexmedetomidine (DEX) in the treatment of increased hemodynamic response during coronary artery bypass. Methods: Following the approval of the Local Committee Research and Ethics Health Research, a controlled randomized clinical trial, in patients undergoing elective coronary revascularization during off-pump coronary artery bypass surgery, was performed under standardized general anesthesia. Patients randomly received infusions of ESM 0,5 mg /kg or DEX 0,5 cg/kg/hr. Hemodynamic variables of study: heart rate and MAP were analyzed at different times: t1) baseline, t2) sternotomy, t3) time of coronary anastomosis and t4) sternal closure. Results: In group DEX, a statistic significance was found in the heart rate sternotomy (t2) p=0,004 and heart rate (t3= time of coronary anastomosis) p=0,026 and MAP during (t3) p=0,002. Conclusions: Although ESM and DEX attenuate hemodynamic response during coronary artery bypass, in the DEX group, hemodynamic stabilization was observed in heart rate and MAP during coronary artery bypass.

Peer review status:UNDER REVIEW

20 Jun 2021Submitted to Journal of Cardiac Surgery
21 Jun 2021Submission Checks Completed
21 Jun 2021Assigned to Editor
13 Jul 2021Review(s) Completed, Editorial Evaluation Pending
14 Jul 2021Reviewer(s) Assigned
09 Aug 2021Editorial Decision: Revise Major
07 Sep 20211st Revision Received
14 Sep 2021Submission Checks Completed
14 Sep 2021Assigned to Editor
14 Sep 2021Reviewer(s) Assigned