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Therapeutic Effect of Steroids on Vestibular Neuritis: Systematic Review and Meta-analysis
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  • Gaeun Kim,
  • Jae-Hyun Seo,
  • Seung Jae Lee,
  • Dong-Hee Lee
Gaeun Kim
The Research Institute for Nursing Science, Keimyung University, College of Nursing
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Jae-Hyun Seo
Seoul Saint Mary's Hospital
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Seung Jae Lee
Medical Library, The Catholic University of Korea
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Dong-Hee Lee
The Catholic University of Korea
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Abstract

Objectives: The present meta-analysis sought to assess further evidence for the efficacy of steroids in vestibular neuritis (VN). Methods: The PubMed, EMBASE and Cochrane Library databases were searched through August 30, 2019. The main outcome measures were 1) complete caloric recovery, 2) improvement of canal paresis (CP) in caloric testing, and 3) dizziness handicap inventory. The follow-up times were divided into short, mid, and long-term. The main outcome measures were 1) complete caloric recovery, 2) improvement of canal paresis (CP) in caloric testing, and 3) dizziness handicap inventory. Results: Among 276 records identified, 5 studies (n = 253) were included in the analysis. The therapeutic effect of steroid on VN was confirmed (Hedges’g = 0.172, 95% CI 0.048 to 0.295, p = .006). This effect was statistically significant on long-term follow-up (Hedges’g = 0.496, 95% CI 0.285 to 0.708, p < .0001). The therapeutic effect of steroids on VN was better than that of non-steroid treatment (Hedges’g = 0.299, 95% CI 0.107 to 0.490, p = .002). However, this effect was obscured by combination of other treatments. The therapeutic effect of steroids on VN was statistically significant regarding complete caloric recovery and improvement in CP (Hedges’g = 0.364, 95% CI 0.181 to 0.547, p < 0.0001; Hedges’g = 0.592, 95% CI 0.315 to 0.5869, p < .0001) Conclusions: The results suggest that corticosteroids are effective at VN recovery, especially in long-term follow-up. More data are required before recommendations can be made regarding management in patients on corticosteroids.

Peer review status:IN REVISION

24 Jun 2021Submitted to Clinical Otolaryngology
29 Jun 2021Submission Checks Completed
29 Jun 2021Assigned to Editor
12 Jul 2021Reviewer(s) Assigned
11 Aug 2021Review(s) Completed, Editorial Evaluation Pending
29 Aug 2021Editorial Decision: Revise Minor
19 Sep 20211st Revision Received
20 Sep 2021Assigned to Editor
20 Sep 2021Submission Checks Completed