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CON: Fomepizole should be used more liberally in paracetamol overdose
  • James Dear
James Dear
Edinburgh University
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Abstract

Fomepizole is a promising new treatment for preventing liver injury following paracetamol (acetaminophen) overdose. However, we need robust clinical trials to be performed to demonstrate its effect on clinical outcomes that are important to our patients and important to healthcare providers. Until such trials are performed, the toxicology community should learn the lessons from the COVID pandemic – potential novel therapeutic options may be theoretically appealing, but their effectiveness needs to be assessed in robust clinical trials before they are used in clinical practice.

Peer review status:ACCEPTED

06 Jul 2021Submitted to British Journal of Clinical Pharmacology
07 Jul 2021Submission Checks Completed
07 Jul 2021Assigned to Editor
10 Jul 2021Reviewer(s) Assigned
18 Jul 2021Review(s) Completed, Editorial Evaluation Pending
20 Jul 2021Editorial Decision: Revise Minor
27 Jul 20211st Revision Received
28 Jul 2021Submission Checks Completed
28 Jul 2021Assigned to Editor
28 Jul 2021Review(s) Completed, Editorial Evaluation Pending
03 Aug 2021Editorial Decision: Accept