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Challenges and Limitations in the Studies of Glycoproteins: A Computational Chemist’s Perspective
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  • Oyku Balli,
  • Vladimir Uversky,
  • Serdar Durdagi ,
  • Orkid Coskuner-Weber
Oyku Balli
Turkish-German University
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Vladimir Uversky
University of South Florida
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Serdar Durdagi
Bahcesehir Universitesi
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Orkid Coskuner-Weber
Turkish-German University Faculty of Science
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Abstract

Experimenters face challenges and limitations while analyzing glycoproteins due to their high flexibility, stereochemistry, anisotropic effects, and hydration phenomena. Computational studies complement experiments and have been used in characterization of the structural properties of glycoproteins. However, recent investigations revealed that computational studies face significant challenges as well. Here, we introduce and discuss some of these challenges and weaknesses in the investigations of glycoproteins. We also present requirements of future developments in computational biochemistry and computational biology areas that could be necessary for providing more accurate structural property analyses of glycopro-teins using computational tools. Further theoretical strategies that need to be and can be developed are discussed herein.

Peer review status:ACCEPTED

11 Jun 2021Submitted to PROTEINS: Structure, Function, and Bioinformatics
24 Jun 2021Submission Checks Completed
24 Jun 2021Assigned to Editor
01 Jul 2021Reviewer(s) Assigned
23 Jul 2021Review(s) Completed, Editorial Evaluation Pending
06 Aug 2021Editorial Decision: Revise Minor
22 Aug 20211st Revision Received
25 Aug 2021Submission Checks Completed
25 Aug 2021Assigned to Editor
25 Aug 2021Reviewer(s) Assigned
25 Aug 2021Review(s) Completed, Editorial Evaluation Pending
07 Sep 2021Editorial Decision: Accept