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Is Ischemia-Modified Albumin a Biomarker in Wagner Classification in Diabetic Foot Ulcers?
  • Sezai ÖZKAN,
  • cihan ADANAS,
  • hamit hakan alp
Sezai ÖZKAN
Van Yüzüncü Yıl Üniversitesi
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cihan ADANAS
Van Yuzuncu Yil Universitesi
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hamit hakan alp
Van Yuzuncu Yil Universitesi
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Abstract

Background: We aimed to determine the relationship of ischemia-modified albumin (IMA) with diabetic foot ulcers and its predictive value in the Wagner classification. Methods: Our cross-sectional study was conducted in 120 diabetic foot patients and 60 healthy individuals with similar body mass index and age. Patients with a diabetic foot were classified according to the Wagner classification. Biochemical parameters, C-reactive protein (CRP) and IMA levels were measured in all patients and healthy volunteers. Screening performance characteristics of CRP and IMA were calculated according to Wagner classes and the presence of osteomyelitis. Results: CRP and IMA levels in the patient group were significantly higher than the control group. The highest IMA levels were detected in Wagner grade 5. CRP had higher sensitivity and specificity than IMA in the discrimination of other grades, except for grade 4-5 separation. For Wagner grade 4-5 distinction, IMA had 84.6% sensitivity and 94.7% specificity. Conclusion: IMA may play a role in the pathogenesis of diabetic foot ulcers and had a higher predictive value in discrimination of the Wagner grade 4 and 5. In the management of diabetic foot patients, it may be recommended that IMA is evaluated by clinicians.

Peer review status:ACCEPTED

30 Apr 2021Submitted to International Journal of Clinical Practice
03 Jun 2021Submission Checks Completed
03 Jun 2021Assigned to Editor
21 Jun 2021Reviewer(s) Assigned
01 Aug 2021Review(s) Completed, Editorial Evaluation Pending
05 Aug 2021Editorial Decision: Revise Minor
28 Aug 20211st Revision Received
28 Aug 2021Assigned to Editor
28 Aug 2021Submission Checks Completed
28 Aug 2021Review(s) Completed, Editorial Evaluation Pending
31 Aug 2021Editorial Decision: Revise Minor
08 Sep 20212nd Revision Received
08 Sep 2021Submission Checks Completed
08 Sep 2021Assigned to Editor
08 Sep 2021Review(s) Completed, Editorial Evaluation Pending
09 Sep 2021Editorial Decision: Accept