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Pregnancy-related changes in Doppler gradients and left ventricular mechanics in women with subvalvular or valvular aortic stenosis.
  • +3
  • Soohyun Chang,
  • Parm Khakh,
  • Mikyla Janzen,
  • Marla Kiess,
  • Valerie Rychel,
  • Jasmine Grewal
Soohyun Chang
The University of British Columbia Department of Medicine
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Parm Khakh
The University of British Columbia Faculty of Medicine
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Mikyla Janzen
The University of British Columbia Faculty of Medicine
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Marla Kiess
The University of British Columbia Faculty of Medicine
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Valerie Rychel
The University of British Columbia Faculty of Medicine
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Jasmine Grewal
The University of British Columbia
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Abstract

Background: The aim of our study was to characterize echocardiographic changes during pregnancy in women with known LVOT obstruction or AS compared to the healthy pregnancy controls, and to assess the relationship with pregnancy outcomes. Methods: We retrospectively studied 34 pregnant patients with congenital LVOT obstruction or AS with healthy age-matched pregnant controls. Patients with other significant valvular lesions, structural heart disease (LVEF <40%), or prior valve surgery were excluded. All LVOTO/AS patients underwent a minimum of 2 consecutive echocardiograms between 1 year pre-conception up to 1 year postpartum, with at least 2 studies during the pregnancy. Comprehensive echocardiographic evaluation was performed including speckle-tracking LV global longitudinal strain. Results: A total of 83 echocardiograms from the study group and 34 echocardiograms from the control group were evaluated. Over the range of LVOTO/AS, a significantly greater increase in the AV gradients and LV and LA volumes were observed as compared with the controls. In the sub-group of LVOTO/AS pregnant women with > moderate (n=8) vs.

Peer review status:ACCEPTED

03 Jun 2021Submitted to Echocardiography
03 Jun 2021Submission Checks Completed
03 Jun 2021Assigned to Editor
20 Jun 2021Reviewer(s) Assigned
04 Jul 2021Review(s) Completed, Editorial Evaluation Pending
06 Jul 2021Editorial Decision: Revise Major
14 Aug 20211st Revision Received
14 Aug 2021Submission Checks Completed
14 Aug 2021Assigned to Editor
14 Aug 2021Reviewer(s) Assigned
17 Aug 2021Review(s) Completed, Editorial Evaluation Pending
22 Aug 2021Editorial Decision: Accept