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Silver Nanoparticles as an Effective Antimicrobial against Otitis Media Pathogens
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  • Rong Yang,
  • Xiaojing Ma,
  • Jiayan Lang,
  • Pengyu Chen
Rong Yang
Cornell University
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Xiaojing Ma
Cornell University
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Jiayan Lang
Cornell University
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Pengyu Chen
Cornell University
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Abstract

Otitis Media (OM) is the most common reason for U.S. children to receive prescribed oral antibiotics, leading to potential to cause antibiotic resistance. To minimize oral antibiotic usage, we developed polyvinylpyrrolidone-coated silver nanoparticles (AgNPs-PVP), which completely eradicated common OM pathogens, i.e., Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) at 1.04µg/mL and 2.13µg/mL. The greater antimicrobial efficacy against S. pneumoniae was a result of the H2O2-producing ability of S. pneumoniae and the known synergistic interactions between H2O2 and AgNPs. To enable the sustained local delivery of AgNPs-PVP (e.g., via injection through perforated tympanic membranes), a hydrogel formulation of 18%(w/v)P407 was developed. Reverse thermal gelation of the AgNPs-PVP-P407 hydrogel could gel rapidly upon entering the warm auditory bullae and thereby sustained release of antimicrobials. This hydrogel-based local delivery system completely eradicated OM pathogens in vitro without cytotoxicity, and thus represents a promising strategy for treating bacterial OM without relying on conventional antibiotics.

Peer review status:ACCEPTED

01 Jun 2021Submitted to AIChE Journal
03 Jun 2021Submission Checks Completed
03 Jun 2021Assigned to Editor
13 Jun 2021Reviewer(s) Assigned
27 Jul 2021Editorial Decision: Revise Major
18 Aug 20211st Revision Received
21 Aug 2021Submission Checks Completed
21 Aug 2021Assigned to Editor
23 Aug 2021Reviewer(s) Assigned
14 Sep 2021Editorial Decision: Accept