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Renal function is associated with one-month and one-year mortality in patients with intracerebral hemorrhage
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  • I-Kuan Wang,
  • Tzung-Hai Yen,
  • Chon-Haw Tsai,
  • Yu Sun,
  • Wei-Lun Chang,
  • Po-Lin Chen,
  • Ta-Chang Lai,
  • Po-Yen Yeh,
  • Cheng-Yu Wei,
  • Cheng-Li Lin,
  • Chi-Yuan Li,
  • Fung-Chang Sung,
  • Chung Y Hsu
I-Kuan Wang
China Medical University Hospital

Corresponding Author:[email protected]

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Tzung-Hai Yen
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Chon-Haw Tsai
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Wei-Lun Chang
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Po-Lin Chen
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Ta-Chang Lai
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Po-Yen Yeh
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Cheng-Yu Wei
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Cheng-Li Lin
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Chi-Yuan Li
China Medical University Hospital
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Fung-Chang Sung
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Chung Y Hsu
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Abstract

Background: This study evaluated short-term (1-month) and long-term (1-year) mortality risks associated with kidney function measured by estimated glomerular filtration rate (eGFR) levels at admission for patients with intracerebral hemorrhage. Methods: From the Taiwan Stroke Registry data, we identified and stratified patients with intracerebral hemorrhage into 5 subgroups by the eGFR levels at admission: ≥ 90, 60-89, 30-59, 15-29, and < 15 mL/min/1.73m2 or on dialysis from April 2006 to December 2016. Risks of 1-month mortality and 1-year mortality rates after intracerebral hemorrhage were investigated by the eGFR levels. Results: Both the 1-month mortality and 1-year mortality rates increased as the eGFR level decreased. The 1-month mortality rate was over 5-fold greater in patients with eGFR < 15 mL/min/1.73m2 or on dialysis than in patients with eGFR levels ≥ 90 mL/min/1.73m2 (8.31 versus 1.50 per 1000 person-days), with an adjusted hazard ratio (HR) of 4.59 [95% confidence interval (CI) = 2.71-7.78]. Similarly, the 1-year mortality rate was 7.5-fold greater in patients with eGFR < 15 mL/min/1.73m2 or on dialysis than in patients with eGFR ≥ 90 mL/min/1.73m2, with an adjusted HR of 4.54 (95% CI 2.95-6.98). Conclusion: The eGFR level can be an indicator of prognosis for patients with intracerebral hemorrhage.