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Primary herpetic oropharyngitis in adults: Differences in clinical features between Herpes simplex virus type 1 and type 2. A retrospective study.
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  • Hideki Nakagawa,
  • Toshiyuki Kusuyama,
  • Makoto Miyamoto,
  • Koichiro Saito,
  • Shunya Ikeda
Hideki Nakagawa
Seibo Byoin

Corresponding Author:[email protected]

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Toshiyuki Kusuyama
Tokyo Voice Clinic
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Makoto Miyamoto
Kyorin University
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Koichiro Saito
Kyorin University
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Shunya Ikeda
International University of Health and Welfare
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Key points 1. This is the first report of adult primary herpetic oropharyngitis in the view point of the differences between the two types of herpes simplex virus (HSV). 2. 41 (25 type 1 and 16 type 2) HSV specific antigen positive cases among 68 immunoserologically confirmed adult HSV primary infection cases were investigated. 3. Significantly low incidence of oral lesions and high incidence of nausea were seen in HSV type 2 oropharyngitis cases, that might mean particular correlation vagus nerve and HSV type 2. 4. Significantly increased white blood cell count and high C-reacative protein value were seen in oropharyngitis by HSV type 2. 5. HSV type 2 possibly cause more severe symptoms and higher inflammatory reactions than type 1, without oral lesions.
12 Apr 2021Submitted to Clinical Otolaryngology
04 May 2021Submission Checks Completed
04 May 2021Assigned to Editor
15 May 2021Reviewer(s) Assigned
26 Sep 2021Review(s) Completed, Editorial Evaluation Pending
03 Oct 2021Editorial Decision: Revise Minor
13 Oct 20211st Revision Received
17 Oct 2021Submission Checks Completed
17 Oct 2021Assigned to Editor
20 Oct 2021Review(s) Completed, Editorial Evaluation Pending
25 Oct 2021Editorial Decision: Accept
Mar 2022Published in Clinical Otolaryngology volume 47 issue 2 on pages 328-330. 10.1111/coa.13888