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Activation of the Hedgehog and Wnt/β-catenin Signaling Pathways in the Immunohistochemistry of Basal Cell Carcinoma


      Immunohistochemical studies have revealed that the tumor of a patient with basal cell carcinoma exhibited activation of the Hedgehog and Wnt/β-catenin signaling pathways. The glioma-associated oncogene1 overexpression leads to transcriptional activation making it an attractive molecular target in anticancer therapies due to the main downstream effectors of the cascade.