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Cardiac structure and function in lowlanders at high altitude: short-term adaptation and chronic remodeling
  • +2
  • guyue liu,
  • liming zhao,
  • qing xu,
  • rong xiao,
  • mingjian lang
guyue liu

Corresponding Author:[email protected]

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liming zhao
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mingjian lang
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Aims: The purpose of this study was to examine cardiac structure and function in lowlanders at high altitude(HA) to investigate short-term adaptation and long-term cardiac remodeling. Methods: In total of 301 healthy subjects included in this study, short-term exposed (STE) and acclimatized lowlanders (AL) at HA, native Tibetans(NT) and sea level residents(SLR) were comprised of 75,77,69 and 80 participants, respectively. Standard echocardiography was performed on all groups, subjects at HA were examined after return to sea level in <24 hours. Results: SBP and HR did not increase significantly after short-term exposure to HA in STE, but increased after long-term exposure in AL, which could be detected even after returning to the plain. Exposure to HA enlarged right heart, widened pulmonary artery and reduced left ventricular(LV) diastolic function in lowlanders. The degree of diastolic dysfunction was more obvious in AL. LV wall thickness increased even after short-term exposure to HA in lowlanders. Ejection fraction did not change significantly in STE, but decreased in AL. Conclusions: Exposure to HA could enlarged the right heart and decrease the diastolic function of LV in lowlanders. The LV systolic function was preserved after short-term HA exposure, but decreased after long-term HA exposure.
13 Apr 2021Submitted to Echocardiography
13 Apr 2021Submission Checks Completed
13 Apr 2021Assigned to Editor
25 Apr 2021Reviewer(s) Assigned
28 May 2021Review(s) Completed, Editorial Evaluation Pending
31 May 2021Editorial Decision: Revise Minor
05 Jun 20211st Revision Received
08 Jun 2021Submission Checks Completed
08 Jun 2021Assigned to Editor
22 Jun 2021Reviewer(s) Assigned
11 Jul 2021Review(s) Completed, Editorial Evaluation Pending
13 Jul 2021Editorial Decision: Revise Major
19 Jul 20212nd Revision Received
19 Jul 2021Submission Checks Completed
19 Jul 2021Assigned to Editor
30 Jul 2021Reviewer(s) Assigned
24 Sep 2021Review(s) Completed, Editorial Evaluation Pending
25 Sep 2021Editorial Decision: Revise Major
25 Oct 20213rd Revision Received
26 Oct 2021Assigned to Editor
26 Oct 2021Submission Checks Completed
26 Oct 2021Reviewer(s) Assigned
25 Jan 2022Review(s) Completed, Editorial Evaluation Pending
25 Jan 2022Editorial Decision: Accept