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Dynamic thiol/disulphide balance in patients undergoing hypotensive anesthesia in elective septoplasties
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  • Leyla Kazancioglu,
  • Sule Batcik,
  • Medeni Arpa,
  • Basar Erdivanli,
  • Zerrin Ozergin Coskun,
  • Ozlem Celebi Erdivanli,
  • Ilkay Bahceci,
  • Hizir Kazdal,
  • Ozcan Erel,
  • Salim Neselioglu
Leyla Kazancioglu
Recep Tayyip Erdogan Universitesi Tip Fakultesi

Corresponding Author:[email protected]

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Sule Batcik
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Medeni Arpa
Recep Tayyip Erdoğan Üniversitesi
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Basar Erdivanli
Recep Tayyip Erdoğan Üniversitesi
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Zerrin Ozergin Coskun
Recep Tayyip Erdoğan Üniversitesi
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Ozlem Celebi Erdivanli
Recep Tayyip Erdogan Universitesi
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Ilkay Bahceci
Recep Tayyip Erdogan Universitesi
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Hizir Kazdal
Recep Tayyip Erdoğan University
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Ozcan Erel
Yildirim Beyazit Universitesi
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Salim Neselioglu
Yildirim Beyazit University
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Objective: We aimed to investigate the effects of hypotensive anesthesia on oxidative stress with serum thiol/disulfide balance in patients undergoing elective septoplasty procedures under general anesthesia. Methods: Seventy-two patients between the ages of 18-60, with a physical condition I –II, according to the American Society of Anesthesiologists, were included in this prospective observational study. Septoplasty was chosen for standard surgical stress. According to the maintenance of anesthesia, patients were divided into the groups as Hypotensive Anesthesia (n = 40) and Normotensive Anesthesia (n = 32). Serum thiol/disulfide levels were measured by the method developed by Erel & Neşelioğlu. Results: The native thiol and total thiol values of both groups measured at the 60th minute intraoperatively were significantly lower than the preoperative values (both p < 0.01). Intraoperatively, at the 60th minute, there was no significant difference in terms of post-native thiol and post-total thiol levels between hypotensive and normotensive anesthesia groups (p = 0.68, and p = 0.81, respectively). Age > 40 years and female gender were found to have a significant effect on dynamic oxidative stress (p = 0.002, and p = 0.001, respectively). Conclusion: This pilot study has found that hypotensive anesthesia had no adverse effect on dynamic thiol/disulfide balance in elective surgeries.
21 Mar 2021Submitted to International Journal of Clinical Practice
22 Mar 2021Submission Checks Completed
22 Mar 2021Assigned to Editor
10 Apr 2021Reviewer(s) Assigned
24 Aug 2021Review(s) Completed, Editorial Evaluation Pending
30 Aug 2021Editorial Decision: Revise Major
07 Sep 20211st Revision Received
08 Sep 2021Submission Checks Completed
08 Sep 2021Assigned to Editor
08 Sep 2021Review(s) Completed, Editorial Evaluation Pending
10 Sep 2021Editorial Decision: Accept