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Procedural efficacy and safety of standardized, Ablation Index guided fixed 50W high power short duration pulmonary vein isolation and substrate modification using the CLOSE protocol
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  • Alexander Francke,
  • Nadja Taha,
  • Frank Scharfe,
  • Steffen Schoen,
  • Carsten Wunderlich,
  • Marian Christoph
Alexander Francke
HELIOS Klinikum Pirna

Corresponding Author:[email protected]

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Nadja Taha
HELIOS Klinikum Pirna
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Frank Scharfe
HELIOS Klinikum Pirna
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Steffen Schoen
HELIOS Klinikum Pirna
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Carsten Wunderlich
HELIOS Klinikum Pirna
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Marian Christoph
Klinikum Chemnitz - MEDIC
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Introduction: Ablation Index guided ablation according to the CLOSE protocol is very effective in terms of chronic pulmonary vein isolation (PVI). However, the optimal RF power remains controversial. Here, we thought to investigate the efficiency and safety of an AI guided fixed circumferential 50W high power short duration (HPSD) PVI using the CLOSE protocol Methods and results: In a single-centre prospective “proof of concept” trial 40 patients underwent randomized PVI using AI guided RF ablation without oesophageal temperature monitoring. In 20 patient fixed 50W HPSD was used irrespective to the anatomical localization. 20 subjects were ablated with standard power settings (20W posterior and 40W roof and anterior wall). Additionally, 80 consecutive patients were treated according to the HPSD protocol to gather additional safety data. All patients underwent post-procedural oesophago-gastro-duodenoscopy to reveal oesophageal lesions (EDEL). The mean total procedural time was 80.3±22.5 minutes in HPSD compared to control 109.1±27.4 (p<0.001). The total RF-time was significantly lower in HPSD 1379±505 sec vs. control 2374±619 sec (p<0.001).There were no differences in periprocedural complications. EDEL occurred in 13% in the HPSD and 10% in control group. EDEL occurring in the 50W HSDP patients were smaller, more superficial and had a faster healing tendency. Conclusions: A fixed 50W HPSD circumferential PVI relying to the ablation index and CLOSE protocol reduces the total procedure time and the total RF time compared to standard CLOSE protocol, without increasing the complication rates. The incidence of oesophageal lesions was similar using 50W at the posterior atrial wall.
31 Mar 2021Submitted to Journal of Cardiovascular Electrophysiology
05 Apr 2021Submission Checks Completed
05 Apr 2021Assigned to Editor
10 Apr 2021Reviewer(s) Assigned
22 Apr 2021Review(s) Completed, Editorial Evaluation Pending
01 May 2021Editorial Decision: Revise Minor
05 Jun 20211st Revision Received
24 Jun 2021Submission Checks Completed
24 Jun 2021Assigned to Editor
24 Jun 2021Reviewer(s) Assigned
01 Jul 2021Review(s) Completed, Editorial Evaluation Pending
07 Jul 2021Editorial Decision: Accept