Is There any Effect of lycopene’s preventing peritoneal adhesion
formation in rats: An Experimental Study
Objective Purpose of the study; to demonstrate the effects of lycopene
on the prevention of intraabdominal adhesions in rats with biochemical,
histological and macroscopic parameters. Material methods Twenty eight
rats were divided into four groups consisting of 7 rats each. Group 1
[only adhesion], Group 2 [adhesion+corn oil], Group 3
[adhesion+ 5 mg/kg lycopene], Group 4 [ adhesion+20 mg / kg
lycopene]. Macroscopic adhesion score, histopathological examination,
Vascular endothelial growth factor (VEGF) H-score, malondialdehyde,
total anioxidant capacity and VEGF values were measured in the groups.
Results There were significantly higher extend [P < 0.05],
severity [P < 0.05], degree [P < 0.05] and
total adhesion [P < 0.05] scores in the control group and
corn-oil group than in the low lycopene group and high lycopene group.
VEGF H-scores were significantly lower in lycopene-given groups,
regardless of dose. When low lycopene group and high lycopene group were
compared in terms of anti VEGF H-score, no significant difference was
observed. Malondialdehyde levels were statistically significantly lower
in the control group and high lycopene group [p<0.05].
Conclusion Biochemical parameters, histopathological examination, and
adhesion scoring revealed that lycopene significantly reduced adhesion