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The voiding dysfunctions in patients with non-Hunner-type interstitial cystitis/bladder pain syndrome do not affect long-term treatment outcome
  • Wan-Ru Yu,
  • Wei-Chuan Chang,
  • Hann-Chorng Kuo
Wan-Ru Yu
Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation

Corresponding Author:[email protected]

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Wei-Chuan Chang
Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation
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Hann-Chorng Kuo
Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University
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Aims: The role of urodynamic studies in the diagnosis and prognosis of interstitial cystitis/bladder pain syndrome (IC/BPS) remains controversial. We evaluated the correlation of baseline voiding dysfunctions with long-term treatment outcome in a large cohort of patients with IC/BPS. Methods: We studied 211 patients with nonulcerative IC/BPS. All patients underwent video urodynamic examination at baseline to identify their voiding conditions and they received subsequent treatments. The primary endpoint was the global response assessment (GRA) at the current interview. Secondary endpoints included O’Leary-Sant score (OSS), Visual Analog Scale (VAS) for pain, and the rate of IC symptom flare-up. Results: Mean patient age was 56.8 ± 12.8 years and mean IC symptom duration was 16.0 ± 9.9 years. At baseline, 83 (39.3%) patients had a voiding problem and 62.7% had one to three comorbidities. The duration, comorbidity, treatments, changes in OSS and VAS, maximum bladder capacity (MBC), glomerulations, GRA, and flare-up rate were not significantly different among the different voiding subtypes. When we divided the patients by their voiding conditions of normal (n = 32) and hypersensitive bladder with (n = 76) and without (n = 103) voiding dysfunctions, only MBC (P = 0.002) and glomerulation (P = 0.021) demonstrated a significant difference. When we analyzed subgroups by GRA, patients with a GRA ≥ 2 had a significantly shorter disease duration. There also were significant associations between GRA and the changes in OSS and VAS (P < 0.001). Conclusions: Voiding dysfunctions in patients with non-Hunner IC/BPS do not affect long-term treatment outcome.
29 Mar 2021Submitted to International Journal of Clinical Practice
30 Mar 2021Submission Checks Completed
30 Mar 2021Assigned to Editor
31 Mar 2021Reviewer(s) Assigned
08 Apr 2021Review(s) Completed, Editorial Evaluation Pending
21 Apr 20211st Revision Received
23 Apr 2021Assigned to Editor
23 Apr 2021Submission Checks Completed
24 Apr 2021Reviewer(s) Assigned
27 Apr 2021Review(s) Completed, Editorial Evaluation Pending
06 May 20212nd Revision Received
06 May 2021Assigned to Editor
06 May 2021Submission Checks Completed
06 May 2021Review(s) Completed, Editorial Evaluation Pending
11 May 2021Editorial Decision: Accept